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Importance of Carbon
Carbon permeates the world of lifefrom the energy-requiring activities and structural organization of cells, to physical and chemical conditions that span the globe and influence ecosystems everywhere.
Organic Compounds
Hydrogen and other elements covalently bonded to carbon Carbohydrates Lipids Proteins Nucleic Acids
Bonding Arrangements
Carbon atoms can
Ball-and-stick model
Space-filling model
Figure 3.3
Ribbon model
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Functional Groups
Atoms or clusters of atoms that are covalently
properties
- CH3
- OH - NH3+ - COOH - PO4- SH
Memorize!
Condensation Reactions
Form polymers from subunits Enzymes remove -OH from one molecule, H
Central carbon
tryptophan (trp)
Protein Synthesis
Peptide bond
Condensation reaction links amino group of one amino acid with carboxyl group of next
Another peptide bond forms. Water forms as a by-product. newly forming polypeptide chain
Primary Structure
Sequence of amino acids
Unique for each protein Two linked amino acids = dipeptide Three or more = polypeptide Backbone of polypeptide has N atoms:
-N-C-C-N-C-C-N-C-C-N-
Hemoglobin
alpha chain beta chain
beta chain
alpha chain
HbS
valine histidine leucine proline threonine valine glutamate
gene Low oxygen causes red blood cells to clump Clumping prevents normal blood flow Over time, may damage tissues and organs throughout the body The gene defect is a known mutation of a single nucleotide (A to T) of the -globin gene, which results in glutamic acid being substituted by valine at position 6.
http://en.wikipedia.org/wiki/Sickle-cell_disease
Nucleotide Structure
Sugar
At least one
ATP
phosphate group
Nitrogen-containing
base
Nucleotide Functions
Energy carriers
Coenzymes
Chemical messengers
acids
DNA
Double-stranded Sugar-phosphate
RNA
Usually single strands
Four types of nucleotides Unlike DNA, contains the base uracil in place of
thymine
Three types are key players in protein synthesis