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epidemiology
Leading cause of death in industrialized world Same risk factors as for atherosclerosis Men more at risk than women; risk gap narrows
for post-menopausal
topography
Epicardial not intramyocardial vessels End circulation
(with potential collaterals that may develop).
O2 supply:
BP Hemoglobin
circumferential
UNSTABLE ANGINA
Onset of chest pain at rest No EKG or biochemical evidence of MI Incomplete occlusion by thrombus and role for vasoconstriction Thrombus embolizes to cause micro-infarct May crescendo May announce MI in evolution
UNSTABLE ANGINA
Onset of chest pain at rest No EKG or biochemical evidence of MI Incomplete occlusion by thrombus and role for vasoconstriction Thrombus embolizes to cause micro-infarct May crescendo May announce MI in evolution
UNSTABLE ANGINA
Onset of chest pain at rest No EKG or biochemical evidence of MI Incomplete occlusion by thrombus and role for vasoconstriction Thrombus embolizes to cause micro-infarct May crescendo May announce MI in evolution
UNSTABLE ANGINA
Onset of chest pain at rest No EKG or biochemical evidence of MI Incomplete occlusion by thrombus and role for vasoconstriction Thrombus embolizes to cause micro-infarct May crescendo May announce MI in evolution
UNSTABLE ANGINA
Onset of chest pain at rest No EKG or biochemical evidence of MI Incomplete occlusion by thrombus and role for vasoconstriction Thrombus embolizes to cause micro-infarct May crescendo May announce MI in evolution
UNSTABLE ANGINA
Onset of chest pain at rest No EKG or biochemical evidence of MI Incomplete occlusion by thrombus and role for vasoconstriction Thrombus embolizes to cause micro-infarct May crescendo May announce MI in evolution
Ischemic Cardiomyopathy
Chronic ischemic heart disease with or without previous MI Diffuse patchy scarring and high-grade coronary stenosis Some hypertrophy possible Subendocardial myocytolysis Heart failure
Ventricular rupture
Cardiac tamponade