Professional Documents
Culture Documents
Study Materials
Copy of these slides Draft, LifePak Monograph
For internal use only. Do not copy!
Nutrition 101
Present Knowledge in Nutrition
Seventh Edition E. E. Ziegler and L. J. Filer, Jr. 1996, 684 pages, $50.00 ILSI Press, 202-659-0074 x123 ilsipress@ilsi.org
y y y y
LifePak & Cardiovascular Health, Glucose & Insulin Metabolism, and Immune Function Key features of other LifePak products LifePak Directions LifePak Safety LifePak Precautions
In other words...
To meet the RDAs, I.e., prevent nutrient deficiencies To improve general well-being, e.g., physical and mental performance To stay healthy (health insurance in pill form)
Multivitamin Usage
38 % of US population are regular multivitamin users! What shall we do with the other 62 %?
RDAs have a safety margin: Less than 2/3rds of RDA = nutrient deficiency
Vi ta
10
20
30
40
50
60
70
80
90
0
A E C
Vi ta Vi ta m in am R in ib of la vi n N ia Vi ci n ta m in B6 Fo Vi la ta m te in B1 Ca 2 lc M i ag um ne si um Iro n Zi n c Th i m in
m in
Males
Females
Optimum RDAs are under development by the NRC Food and Nutrition Board (NRC FNB)
Optimum Supplementation
Ensures RDA levels + Considers typical dietary intakes + Optimum nutrient levels for long-term health + Non-essential, beneficial nutrients
What is LifePak?
LifePak is a comprehensive nutritional supplementation program delivering the optimal amounts of all essential vitamins, antioxidants, minerals, and trace elements, as well as beneficial phytonutrients.
LifePak Advantages
LifePak is FIVE formulas in one:
1. high potency antioxidant formula 2. balanced B-vitamin formula 3. complete bone support formula 4. complete trace element supplement 5. phytonutrient formula
Antioxidants
Capture/neutralize free radicals
(e.g., vitamin E in cell membranes, etc.)
Intrinsic Antioxidants:
albumin, uric acid, a-ox enzymes (GPX, SOD, catalase), and others.
Antioxidant Effects
Decrease free radical damage (oxidation)
especially in people with high oxidative stress:
smokers, elderly, people in polluted urban areas
Antioxidants
Many types of antioxidants must work together (in synergy) to afford effective protection from free radical damage. Antioxidant defense system
LifePak Antioxidants
Vitamin C, 500 mg Vitamin E, 300 IU, natural Selenium, Zinc, Copper, Manganese alpha-Lipoic acid Phytonutrients:
Carotenoids Flavonoids
Serum F-Carotene
(nmol/L)
1200 1000 800 600 400 200 0 Baseline Endpoint
331
335 716
PL MVMS
299
Serum E-Carotene
(nmol/L)
1000 800 600
592
PL MVMS
400 200
122
77
85
Baseline
Endpoint
Serum Vitamin C
(Qmol/L)
140 120 100 80 60 40 20 0 Baseline Endpoint
67.4 68.1 70.6 94.3
PL MVMS
Serum Vitamin E
(Qmol/L)
50 40 30 20
19.9 20 20.6 36.9
PL MVMS
p < 0.001
10 0 Baseline Endpoint
Serum Selenium
(Qmol/L)
4 PL MVMS 3
2.3
2.5
p < 0.01
2.2
2.1
0 Baseline Endpoint
LDL Oxidation
y
LDL are prone to oxidation by free radicals. Oxidized LDL tend to adhere to artery walls more than non-oxidized LDL. Antioxidants can improve LDLs resistance against free-radical oxidation
LDL Oxidizability
LDL
LDL
LDL
LDL Oxidizability
Oxidation
PL MVMS
p < 0.001
40 30 20 10 0
42.1
43.4
42
Baseline
Endpoint
PL MVMS
LP Studies: Conclusions
LifePak improved antioxidant status. LifePak increased LDLs resistance against free-radical oxidation, and thus, may have cardiovascular benefits. LifePak is safe and well-tolerated.
LifePak Advantages
LifePak is FIVE formulas in one:
1. high potency antioxidant formula 2. balanced B-vitamin formula 3. complete bone support formula 4. complete trace element supplement 5. phytonutrient formula
LifePak B-Vitamins
Balanced accdg. to optimum requirements. Optimum amounts for normal homocysteine metabolism.
Homocysteine: Undesirable amino acid byproduct from methionine metabolism impairs vascular function, atherogenic independent risk factor for cardiovascular disease B12, Folate & B6 help control homocysteine.
LifePak B-Vitamins
Regular LifePak B-Vitamins:
Thiamin (vitamin B1) Riboflavin (vitamin B2) Niacin Vitamin B6 (pyridoxine) Folic Acid Vitamin B12 Pantothenic Acid Biotin 3 mg 3.4 mg 40 mg 10 mg 600 mcg 30 mcg 30 mg 300 mcg 200 % DV 200 % DV 200 % DV 500 % DV 150 % DV 500 % DV 300 % DV 100 % DV
LifePak Advantages
LifePak is FIVE formulas in one:
1. high potency antioxidant formula 2. balanced B-vitamin formula 3. complete bone support formula 4. complete trace element supplement 5. phytonutrient formula
y y y
Calcium (Ca) is the major bone mineral, and it helps prevent osteoporosis. Calcium intake: 55% of men and 78% of women do not meet the RDA! Calcium RDA = RDI (DV): 1,000 mg/day 1 gl. of milk = 300 mg calcium = 30 % DV LifePak has 500 mg Ca = 50 % DV
Bone Nutrition
LifePak Advantages
LifePak is FIVE formulas in one:
1. high potency antioxidant formula 2. balanced B-vitamin formula 3. complete bone support formula 4. complete trace element supplement 5. phytonutrient formula
Chromium AA Chelate Manganese AA Chelate Molybdenum AA Chelate Silicon (metasilicate) Boron (citrate)
LifePak Advantages
LifePak is FIVE formulas in one:
1. high potency antioxidant formula 2. balanced B-vitamin formula 3. complete bone support formula 4. complete trace element supplement 5. phytonutrient formula
Phytonutrients
A.k.a. phytochemicals or secondary plant metabolites. Non-essential plant compounds with health benefits. Over 12,000 phytonutrients have been isolated from foods.
LifePak Phytonutrients
LifePak provides a broad spectrum of:
LifePak Phytonutrients
Carotenoids:
y y y y y y
over 600 carotenoids present in nature safe vitamin A sources (a- & b-carotene) fat-soluble antioxidants (1O2 quenchers) promote immune function (b-carotene) prevent prostate cancer (lycopene) prevent macular degeneration (lutein)
Phytonutrients
Beta-Carotene: Friend or Foe?
y
high-dose (20-30 mg) synthetic beta-carotene may promote existing lung tumors (ATBC study, CARET study). Population studies: beta-carotene decreases risk for most cancers, incl. lung cancer. Other carotenoids have been ignored in research. Most are more potent antioxidants.
Phytonutrients
Beta-Carotene: Friend or Foe?
Recommendations: y Eat more fruits & vegetables! y Pharmanex - IDN position: Supplementation is beneficial:
y with a broad spectrum of dietary carotenoids y at physiologic levels y reflecting carotenoids from fruits & vegetables
LifePak Phytonutrients
LifePak Carotenoids:
beta-Carotene (D.salina) 6 mg (10,000 IU) lutein (Marigold extract) 2 mg lycopene (Tomato extract) 1 mg alpha-Carotene 2 mg Zeaxanthin beta-Cryptoxanthin (extracts conform to Pharmanex 6S Process)
LifePak Phytonutrients
Flavonoids:
y O
y y y y
over 5,000 flavonoids known in nature, 600 present in our diets. water/alcohol soluble plant products powerful antioxidants many enhance microcirculation (blood flow) many appear to prevent cancer (epidemiological, animal studies)
LifePak Phytonutrients
LifePak Flavonoids (145 mg total):
y
y y
Amount } 5-10 servings of fruits & veggies All extracts conform to 6S Process
B-Vitamins: maintain normal blood homocysteine Flavonoids: promote normal platelet aggregation
and blood microcirculation
Vitamins C & E:
promotes cell-mediated specific and non-specific immunity
beta-Carotene, carotenoids:
promotes natural killer cell activity
LifePak Women
LifePak Women
Young, Pre-Menopausal Women
Key Features:
Bone Nutrition: 1,000 mg calcium & 500 mg magnesium (2x LifePak!), & extra silicon;
National Insitutes of Health: 1,000 - 1,500 mg Ca/day About 80% of young women do not meet RDA (1,000 mg) FDA Health Claim: Calcium prevents osteoporosis
LifePak Women
Key Features, continued
Folate and Inositol: For women in their childbearing years;
Folate prevents neural tube defects (FDA health claim)
Special Phytonutrients:
25 mg soy isoflavones: same as in 25 grams soy protein gamma-linolenic acid-rich oils.
LifePak Prime
LifePak Prime
For Post-Menopausal Women & Men Over Age 40
Key Features:
Bone Nutrition: 1,000 mg calcium & 500 mg magnesium (2x LifePak!), & extra silicon
NIH: 1,000 - 1,500 mg calcium per day
LifePak Prime
Key Features, continued:
Glucosamine: 200 mg
promotes joint structure & function 200 mg doubles average dietary intake
Special Antioxidants: glutathione, N-acetylcysteine, coenzyme Q10 Extra Phytonutrients: More curcumin, grape seed OPCs; added stdzd. Ginkgo extract and Milk Thistle extract.
LifePak PreNatal
LifePak PreNatal
For Pregnant & Lactating Women
Key Features:
Optimum Antioxidants: 150 IU natural vitamin E & 300 mg buffered vitamin C
may prevent pre-eclampsia (gestational hypertension) pre-eclampsia affects 5-15 % of pregnant women
LifePak PreNatal
Key Features, continued:
Folate and Inositol: 800 mcg, 500 mg
prevent neural tube defects
LifePak PreNatal
Key Features, continued:
Vitamin A: 5,000 IU is safe and effective
Supplementation with more than 10,000 IU of preformed vitamin A may increase the risk for fetal damage (teratogenic effects).
TM
THE PROBLEM: Over 60% of teen boys and over 80% of girls dont meet the RDA for calcium or magnesium*
*USDA CSFII 1994-96 Survey Data
THE SOLUTION: LifePak Teen Bone Nutrients: 500 mg Calcium 200 mg Magnesium 400 IU Vitamin D 40 mcg Vitamin K 3 mg Boron 3 mg Silicon
THE PROBLEM: THE SOLUTION: Not enough antioxidant vitamins: Over 60% of teens dont get the RDA for vitamins A & E*
*USDA CSFII 1994-96 Survey Data
LifePak Teen Antioxidants 5,000 IU Vitamin A 3 mg F-carotene 100 IU Vitamin E 200 mg Vitamin C 70 mcg Selenium
THE PROBLEM: THE SOLUTION: Not enough iron: 72.5% of girls ages 1219 dont meet the RDA for iron*
*USDA CSFII 1994-96 Survey Data
THE PROBLEM: THE SOLUTION: Not enough zinc: Over 65% of teens dont meet the RDA for zinc*
*USDA CSFII 1994-96 Survey Data
LifePak Safety
y
All vitamin & mineral levels are below the NOAEL (No Observed Adverse Effect Level) established by the CRN (Council for Responsible Nutrition, 1998). Phytonutrients are added at levels that are documented safe. Clinical studies showed no adverse effects to LifePak
LifePak Directions
One packet twice daily with meals
meals enhance absorption (vitamins) and improve tolerance (minerals) twice daily promotes steady nutrient delivery, e.g., plasma levels of vitamin B6:
7:30 AM
6:30 PM
LifePak Precautions
Pregnant & lactating women, diabetics, hypoglycemics, and people with known medical conditions should consult with a physician before taking supplements
LifePak Substantiation
Over 1,000 peer-reviewed scientific papers on file documenting the efficacy and safety of all nutrients in LifePak.
LifePak Substantiation
No other complete multi-nutrient supplement has ever been subjected to two well-designed double-blind clinical studies to show antioxidant effects in healthy people.
In other words...