Journal Article Review

Journal article review
By: Dr Haresh E. Memane Final year P.G. Scholar Department of Dravyaguna
Contents
Objectives of seminar Article Scope of article Abstract Introduction Critical analysis Own research view Summary Conclusion
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Objectives
To review the article critically.
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Title
SOME IMPORTANT ANTICANCER HERBS: A REVIEW
Author
Pandey Govind* Ex-Professor / Principal Scientist & Head of Pharmacology (Pharmacy); presently Officer-In-Charge of Rinder Pest (Animal Husbandry Department, Govt. of MP), Jabalpur Division, Jabalpur, MP, India Article Received on: 12/05/11 Revised on: 20/06/11 Approved for publication: 08/07/11
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Abstract
A great deal of pharmaceutical research has considerably improved the quality of herbal drugs used against various types of cancer. With the advanced knowledge of molecular science and the refinement in isolation and structure elucidation techniques, we are in a much better position now to identify various anticancer herbs.
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Cont
Scientists all over the world are concentrating on the use of herbs to boost immune system of the body against cancer. Scientists have contributed for a number of years to identify hundreds of anticancer herbs, and developed various herbal formulations from their active principles that inhibit growth and spread of cancer without any side effect.
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Cont .
Such herbs possess anticancer, immunoenhancing, antiangiogenesis, antioxidant and antimutagenic properties. They inhibit growth and spread of cancer by modulating the activity of hormones, enzymes and other biological factors. The therapeutic effect of these herbs is executed by the complex synergistic interaction among their various active principles. Some important anticancer herbs have been
discussed here.
KEYWORDS: Anticancer activities, Cancers, Herbs/medicinal plants, Phytoconstituents.
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Introduction
Review article contains 35 anticancer herbs (anticancer medicinal plants). The general data of these plants have been collected from some books authored by different authors. The particular phytoconstituents (phytochemicals) present in these plants, their mechanism of action and uses against the various cancers as reported by different authors have been cited under each medicinal
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plant/herb.
Cont .
The anticancer activity of the medicinal plants is
because of the presence of certain phytoconstituents, which possess strong antioxidant activities. The main phytoconstituent antioxidants with anticancer activity include vitamins (e.g., A, C, E and K), carotenoids or carotene, terpenoids, flavonoids, polyphenols (e.g.ellagic acid, gallic acid and tannins), flavonoids (e.g.,quercetin, anthocyanins,
2/1/2012 Journal article review catechins,isocatechins,flavones, flavonones and 10
Cont ..
Enzymes (e.g. superoxide dismutase, catalase and glutathion peroxidase), minerals (e.g., selenium, copper, manganese,zinc,chromiumandiodine),polysaccharides, alkaloids, saponins, lignins, xanthones and certain pigments.
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Anticancer herbs
Name of plants Aegle marmelos Correa Rutaceae Phytochemical Lupeol Specific actions Breast cancer, malignant cancer , malignant lymphoma, ascites, leukamia Inhibit Helicobactor pylori, stomach cancer Stomach , lung, colon,liver, breast and endometrial cancer. Inhibit growth and spread of stomach cancer. Prostate , multiple myeloma, leukaemia
Allium cepa Linn Liliaceae Allium sativum Linn Liliaceae Aloe vera Tourn Liliaceae Alpinia galanga Willd Zingiberaceae
Diallyl disulphide, quercetin flavonoids Sulphur compounds , allicin Acemannan ( Polysaccharide) , Emodin Acetoxy-chavicol-acetate , Galangin
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12
Name of plants Curcuma longa Linn Zingiberaceae
Phytochemicals Curcumin ( Diferuloyl methane )
Specific actions Suppress cancer at every step i.e, initiation , growth, metastasis ( Suppresses adhesion of cancer cells) Breast , ovary, stomach, colon, prostate,kidney and nasopharynx Breast , ovary, cervix,lung, colon, rectum,kidney and testis cancers Breast, uterus, pancreas,stomach and malignant ascites Breast , lung , liver, oral cavity, larynx.
Andrographis paniculata Wall Acanthaceae Catharanthus roseus G. Apocyanaceae Emblica officinalis Gaertn Euphorbiaceae Bauhinia variegata Linn Caesalpiniaceae
Andrographolide ( Active diterpine component ) Vinca alkaloids
Ellagic , gallic acid, quercetin Cyanidin glucosides, malvinin glucosides
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Name of plants Ginkgo biloba Linn. Ginkgoaceae Viscum album Linn. Loranthaceae Panax ginseng Mey. Araliaceae Malus domestics Borkh. Rosaceae Fragaria vesca Linn. Rosaceae
Phytochemicals Ginkgetin , ginkgolides Lectins Ginsenosides
Specific actions Hepatocellular carcinoma Urinary bladder, testis, leukaemia Prostate,colon,renal cell carcinoma, malignant melanoma Antioxidant , anticancer
Flavonoides , tannins, borneol
Antioxidant, anticancer
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14
Name of plants Nigella sativa Linn. Ranunculaceae Tinospora cordifolia ( Willd) , Menispermaceae Rubia cordifolia Linn. Rubiaceae Oldenlandia diffusa Roxb. Rubiaceae Punica granatum Linn. Punicaceae
Phytochemicals Thymoquinone, Diathymoquinone Berbarine , tinosporine Rubidianin , rubiadin Oldenlandosides, ursolic acid Alkaloides , anthocyanidines
Specific actions Colon,prostate,pancreas,ut erus,sarcomas Cancer of lung,cervix and throat. Breast,ovary,cervix and lung cancers Lung,ovary,colon,rectum and brain Acts against solid and ascites tumour
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15
Name of plants Saussurea lappa C.B.Clarke Asteraceae Solanum nigrum Linn. Solanaceae Withania somnifera Dunal Solanaceae Plumbago zeylanica Linn. Plumbaginaceae
Phytochemicals Sesquiterpenes , Cynaropicrin Quercetin , solamargine, solamergic Withanolides , withaferin Plumbagin
Specific actions Malignant lymphoma and leukaemia Breast,liver,lung and cyst cancers Breast,lung,colon,CNS Liver cancer, fibrosarcoma,malignant ascites and leukamia
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Name of plants Gycine max Merrill Fabaceae Glycyrrhiza glabra Linn. Fabaceae Psoralea corylifolia Linn. Fabaceae Ocimum sanctum Linn. Labiatae Prunella vulgaris Linn. Labiatae
Phytochemicals Isoflavones , saponins , Genistein Triterpenoi saponins Bavachinin , corylfolinin Ursolic acid , polysaccharides
Specific actions Nasopharyngeal carcinoma, skin cancer, malignant brain tumours Antitumour, lung cancer and fibrosarcomas Lung,liver,osteosarcoma, Leukaemia. Breast,liver cancer,sarcomas
Ursolic acid , oleanolic acid Oral cavity,oesophagus, intracranial tumours,AntiHIV , immunoenhancing.
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Name of plants Aphanamaxis polystachya (Wall) , Meliaceae Azadirachta indica A.Juss. Meliaceae Berberis vulgaris Linn. Berberidaceae Podophyllum hexandrum Royle. , Berberidaceae
Phytochemicals Amooranin
Specific actions Multidrug resistant in breast ,colon cancer and leukamia Prostate, stomach and skin cancers Stomach and oral cavity cancers Urinary bladder, testis, brain and neuroblastoma.
Liminoids Berbarine , berbamine Podophyllotoxin , podophyllin
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Critical analysis
Review article In vitro and in vivo studies in animals have been carried out on these herbs. Anticacer medicinal plants - 35 anticancers herbs - Latin name, Local name, Family of herbs - Based on phytoconstituents. - Phytoconstituent with antioxidants and anticancer activity. - Reduces side effects of chemotherapy and radiotherapy.
Cont .
Maximum herbs from liliaceae, zingiberaceae,rosaceae,rubiaceae,solanaceae, fabaceae, labiatae and berberidaceae families. Antioxidant, hepatoprotective, neuroprotective and immunoenhancing properties. Radioprotective and haemopoietic properties. W. somnifera presents itself as a novel therapy for cancer.
2/1/2012 Journal article review No discussion and conclusion. 20
Own research view

Clinical studies can be carried out on these herbs.
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21
Summary
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Conclusion
Anticancer drugs which are mentioned in article mainly based on phytoconstituents. Phytoconstituent with antioxidants and anticancer activity. Most of the drugs reduces side effects of chemotherapy and radiotherapy.
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Thank you

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Journal article review

By: Dr Haresh E. Memane Final year P.G. Scholar Department of Dravyaguna