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Original Titles
Cancer: Striking the Root vs. Cancer: Dont Kill the Messenger
The problem is, when we treat cancer cells with chemotherapy, the cancer stem cells are being stimulated to grow too. When we take mesenchymal stem cells and mix them with tumor cells, the tumors grow much more quickly in animals.
The Weeks Clinic for Corrective Medicine and Psychiatry 2011
Max Wicha: Hopes cancer treatments can avoid general chemo altogether and just use targeted therapies against the stem cells. Max Wicha is coming to Pittsburgh today to deliver a startling message. Standard cancer treatments not only often fail to eradicate cancer, but can make it worse. That argument isn't coming from a fringe proponent of alternative medicine, but from the founder of the University of Michigan's Comprehensive Cancer Center and a pioneer in research on why cancers recur and spread to other parts of the body.
The Weeks Clinic for Corrective Medicine and Psychiatry 2011
An article published by the Post-Gazette claimed that our research suggests cancer treatments "not only often fail to eradicate cancer, but can make it worse" This statement has been misinterpreted by patients currently receiving radiation or chemotherapy treatments. I have been contacted by both my own patients and Pittsburgharea patients who have questioned whether they should continue with their chemotherapy. In fact, these treatments are lifesaving for many patients.
The Weeks Clinic for Corrective Medicine and Psychiatry 2011
Retraction
(cont.)
Our work does suggest that the resistance of a small population of tumor cells to these treatments may account for some of their limitations. Based on this, we are working to develop new approaches to target this specific cell population -- treatments that could augment chemotherapy and radiation therapy. New treatments based on this theory are in their early testing stages. Only through the conduct of rigorous clinical trials will we be able to determine whether addition of these new therapies improves the outcome for patients with cancer. In the meantime, patients diagnosed with cancer need to follow their doctors' recommendations for treatment according to the current standards of care and inquire whether they are eligible for a clinical trial. MAX WICHA, M.D. Distinguished Professor of Oncology Director, University of Michigan Comprehensive Cancer Center Ann Arbor, Mich.
Brief Review
Know your enemy intimately, See your target clearly, Set your strategy carefully, Before you attack wisely.
Leading Thought: Is attacking Cancer the Best Strategy? The ideal strategy whereby one could win without fighting, accomplish the most by doing the least, bears the characteristic stamp of Taoism.
- note by Thomas Cleary, translator, of Sun Tzus The Art of War
The Weeks Clinic for Corrective Medicine and Psychiatry 2011
What is Cancer?
Cancer is understood to be unregulated cells proliferating autonomously within the human being either in humoral or tumorous form. (Query: Are these aggressive or confused cells?)
What is a Tumor?
A tumor, benign or malignant, is a proliferation of cells of which, in the case of a malignant cancer, less than 1% of which are dangerous.
Interesting Fact
99.1% - 99.6% of the tumor cells are NOT dangerous (aside from steric, obstructive factors).
Similarly, usually less than 1% of primary tumor cells cultured in vitro can give rise to colonies.
Diehn, M Therapeutic Implications of the Cancer Stem Cell Hypothesis Semin Radiat Oncol. 2009 April; 19(2): 7886.
What metastasizes?
Stem cells!
tumor cells are heterogeneous in their capacity to give rise to tumors upon transplantation or to form colonies in culture assays. For in vivo tumor transplantation, this is reflected in the large numbers of tumor cells that must usually be transplanted to form a tumor. For primary human and mouse tumors, this number often resides in the thousands or millions. (ibid Diehn et al)
Chemotherapy and Radiation is only effective in non-aggressive cancer cells (tumor cells, not cancer stem cells).
Invasive Carcinoma
Chemo-Therapy Radiation
Linheng Li and William B. Neaves Cancer Res 2006; 66: (9). May 1, 2006
Chemotherapy or Radiation
Invasive Carcinoma
Resistence!
Normal cell
Cytokines which inhibit Stem Cell Differentiation are increased by doxorubicin in H460 tumor cells, In vitro
Levina et al. Chemotherape utic drugs and human tumor cells cytokine network. Int J Cancer. 2008
Going Forward
Assessing the efficacy of such treatments will require the advent of new approaches to assessing CSC frequency and viability within tumors. Furthermore, classic mechanisms of treatment resistance, such as clonal selection and the tumor microenvironment, will continue to present obstacles for achieving cure. It is therefore likely that combinations of cytotoxic, biologic, and CSC-directed therapies will ultimately allow the largest possible improvements in patient outcomes.
But.
IPT, being chemotherapy (albeit low dose and targeted kinder and gentler) nevertheless still worsening cancer prognosis since it still kills ONLY cancer tumor cells (not the cancer stem cells): the resulting IL-8 SOS signal still goes out to muster reinforcements from the mesenchymal stem cells which increase the number and virulence of cancer stem cells.
Adjunctive therapies along with IPT to entice cancer stem cells to differentiate and become normal tissue stem cells or normal tissue cells.
(cont.)
The goal of the Cordelia Effect (Corrective Cancer Care) is to control the variables including the local tumor environment so as to shift the cancer stem cells metabolism away from proliferation and towards differentiation, in order to decrease tumor size, growth and virulence.
The Weeks Clinic for Corrective Medicine and Psychiatry 2011
1) Proteolytic Enzyme Therapy (pancreatic enzymes) 2) MEBO (moist exposed burn ointment) 3) Anti-inflammatory agents (tumeric, etc.) 4) Fermented Soy products (Haelan 951)
Proteolytics Enzymes
MEBO
Moist Exposed Burn Ointment
Create a healthy environment which allows nutrition, detoxification and differentiation for cancer stem cells wherein cancer can not persist. Therapy in concordance with the human beings powerful momentum towards health.
Tumors are wounds, that do not heal. Every cancer medication should improve wound healing.
- Rudolph Virchow, 1865
Today we know that cytokines (inflammation) inhibit cell differentiation and wound healing.
Anti-Inflammatory Agents
Goal: To interrupt the IL-8 cytokine SOS and allow differentiation of cancer stem cells
Reprotaxin -CXCR1 receptor blocker- (Wicha) Oxygen (hypoxemia stimulates CSCs) Tumeric MEBO Fermented Soy
Isoflavone
(125/Tag)
Nach Einnahme
30
20
10
0 -5 0 5 10 15 20 25 Zeit (Wochen)
We have shown that the dihydrotestosterone metabolite 5alphaandrostane-3beta,17beta-diol (3beta-Adiol), a steroid which does not bind androgen receptors, but efficiently binds the estrogen receptor beta (ERbeta), exerts a potent inhibition of prostate cancer cell migration through the activation of the ERbeta signaling.
The Weeks Clinic for Corrective Medicine and Psychiatry 2011
Note: in the Blood Circulating Tumor Cells are more aggressive Than the primary tumor : Less Differentiated !!!!!
Rohr et al 2010
300
200
100
0 0
1,5
Time (Month)
Single Cases
Single Cases
Ovary Ca
untreated With fermented soy
N= 164
N= 78
Chemotherapy + Placebo
In leukemic Children increases a) transplant efficiency and b) reduces hospital stay of children
4 month with Conventional transplantation
1 1/2 month if treated with fermented soy Dramatic increase of Cell differentiation
Anti-Angiogenesis
Stabilizing blood capillaries in cancer patients is the new goal in severe diseases. Adiol (and/or Fermented Soy) inhibits stem cell metastastasis by this anti-inflammatory mechanism.
Trauma
Fermented Soy transforms Resistant Cancer Stem Cells into differentiated cancer cells which can then be treated with Chemo or Radiation therapy.
Cancer Stem Cell Differentiating
Primary
Invasive Carcinoma
Mets
Chemotherapy
Radiation
Fermented Soy
Normal Cell
Fermented soy transformed circulating cancer stem cells (in vivo, human) into more differentiated and therefore more targetable treatable cancer tumor cells.
This mechanism may be the reason for dramatic increase in survival we see in clinic.
An example of the Cordelia Effect
(cont.)
6) IPT, while kinder and gentler, must not be given unless adjunctive care is taken to minimize cancer stem cell stimulation 7) Adjunctive treatment modalities represent a significant improvement over traditional IPT.
8) This is a therapeutic message which our patients, as well as our oncology colleagues, are ready to hear.
The Weeks Clinic for Corrective Medicine and Psychiatry 2011
Paracelsus
1493 - 1541
The Weeks Clinic for Corrective Medicine and Psychiatry 2011
Sirens sang from Science rocks and caught my ear, despite the plug nestled deep of orthodox which churches plant, so proud and smug. Orphans each adrift we are; homeless, steering course by star. The winds would change, time was short. The moment asked of me resolve. So digging deep within my heart, I chose, swung prow, intent to solve the only question man must ask; the only truly human task
For the rest of the epic poem, see Appendix and http://weeksmd.com/?p=5456
6) The Enzyme Treatment of Cancer and its Scientific Basis John Beard, D. Sc. 1911 7) The Trophoblast and the Origins of Cancer Nicholas Gonzalez, M.D. New Spring
Press 2009
People to Watch
Max Wicha, M.D. (Dir. U. Michigan Cancer Center) Michael Clark M.D. Dir. Stanford Institute for Stem Cell & Regenerative Medicine. Max Diehn M.D. (Oncology radiologist Stanford) Ursula Jacob, M.D. and Walter Wainright (Haelan) Xu Rongxaing, M.D. (MEBO) John Beard, M.D. (deceased) / Nicholas Gonzales, M.D.
The Weeks Clinic for Corrective Medicine and Psychiatry 2011