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❚ Respiratory airways
❙ Nasal passages
❙ Pharynx
❙ Trachea
❙ Bronchi
❙ Bronchioles
Structure of the
Respiratory System
Interstitial fluid
Alveolus
Pulmonary
capillary
Erythrocyte
Structure of the
Respiratory System
❚ Lungs, contd.
❙ Pulmonary capillaries
❙ Elastic connective tissue
❙ Pleural sac
❚ Thorax
Respiratory Mechanics
Air moves from an area of high
pressure to an area of low
pressure, following the pressure
gradient.
Respiratory Mechanics
❚ Pressure considerations
❙ Atmospheric pressure
❙ Intra-alveolar pressure
❙ Intrapleural pressure
Major Inspiratory Muscles
❚ Quiet breathing
❙ Diaphragm
❙ External intercostal muscles
❚ Deeper inspirations
❙ Accessory inspiratory muscles
Expiration
❚ Bronchoconstriction -
parasympathetic stimulation
❚ Bronchodilation - sympathetic
stimulation
Airway Resistance
Lung Elasticity
❚ Normal range:
❙ Male - 5.7 liters
❙ Female - 4.2 liters
❘ 500 ml of air are inspired and expired
❘ At end of quiet expiration, the lungs
still contain 2,200 ml of air
Lung Volumes
❚ Tidal volume
❚ Residual volume
❚ Vital capacity
❚ Total lung capacity
❚ Forced expiratory volume in one
second
Alveolar Ventilation
❚ Pulmonary ventilation
❚ Respiratory Rate
❚ Anatomical dead space
❚ Alveolar ventilation
❚ Alveolar dead space
Local Regulation
❚ Surface area
❚ Thickness of the membrane
❚ Diffusion coefficient of the particular
gas.
Rate of Diffusion
❚ Oxygen
❙ Dissolved oxygen (1.5%)
❙ Chemically bound to hemoglobin
(98.5%)
❚ Plateau portion
❙ Range that exists at the pulmonary
capillaries.
❚ Carbon dioxide
❚ Acidity
❚ Temperature
❚ Carbon Dioxide
❙ Dissolved CO2 (10%)
❙ Carbamino hemoglobin (30%)
❙ Bicarbonate (60%)
❙ Chloride shift
❚ Neural control
❚ Chemical stimuli
Neural Control
❚ Arterial PO2
❚ Arterial PCO2
❚ Arterial H+
Arterial PO2
❚ Monitored by peripheral
chemoreceptors
❚ PO2 must fall below 60 mm Hg to
stimulate increased respiration
❚ Peripheral chemoreceptors respond
to the PO2 and not the total oxygen
content.
Arterial PCO2
An oxyhemoglobin saturation of
systemic venous blood of 25% for a
person at rest is:
a. above normal
b. below normal
c. within the normal range
Respiratory Questions