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Age-related reductions in muscle mass are a direct cause of declines in muscle strength with aging. This reduction in muscle strength is a major cause of disability in the older adult since strength and power are major components of gait, balance, and the ability to walk.
For example, in the third or fourth decade of life, the mean crosssectional area of individual fast-twitch type II fibers in the quadriceps femoris muscle exceeds that of slow-twitch type I fibers by approximately
20%.
By the age of 85 the area of individual fast-twitch type II fibers is less than 50% of that of slow-twitch type I fibers.
diseases.
5-Axon
The loss of motor neurons is accompanied by a reduction in both the numbers and diameters of motor axons. There is an age-related reduction in the numbers of large and intermediate myelinated ventral root fibers but no significant reduction of the small nerve fibers. Quantitative electromyography (EMG) has shown changes in both duration and amplitude of motor unit action potentials with increasing age. Axonal nerve conduction velocities of all motor nerve fibers are slowed with aging. This suggests that with aging, the alterations in conduction velocities could reflect a variety of changes in the nerve fibers, such as segmental demyelination, and a reduced internodal length. In addition, the mean soma size of motor neurons is reduced with age with accumulation of lipofuscin.
1-Strength
Age-related decreases in strength have been welldocumented. Healthy men and women in their seventh and eighth decades of life demonstrate average reduction of 20% to 40% in maximal isometric strength in various muscles. Arm, leg, and back strength decline at an overall rate of 8%
30%).
Weight-bearing muscles showed greater changes than nonweight-bearing muscle.
It is conceivable that age related weakness may be caused by: 1) Decreased central drive and thus a decrease in ability to voluntarily activate a muscle. The threshold of excitability of the corticospinal tract increases progressively with age and is significantly higher in the elderly.
muscle fibers.
2- Power
The power output is governed by:
(1) The velocity of shortening and (2) The force-generating capacity of the muscle.
3-Endurance
A decline in muscular endurance is a feature of old age that contributes to functional loss and disability. Alterations in muscle, both contractile and metabolic, with advanced age may contribute to the decrease in muscle endurance. The alterations include :