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Anaemias
What is Bone marrow failure ?
Primarily caused by stem cell injury
Inability of the BM to produce sufficient marrow
cells which include RBC, WBC and platelets
PANCYTOPENIA
Very Severe
• Neutrophils<0.2x109/l
• Infection present
Diagnostic criteria
.
Diagnostic approach to the patient with
pancytopenia
Diagnostic approach to Pancytopenia
• History – medications, previous chemotherapy or
radiation, toxic exposure, HIV risk factors, family history
• Physical examination – congenital anomalies,
organomegaly or lymphadenopathy
• Investigations – FBC, retics, smear, Vit B12 and folate,
LFTs, Connective tissue screen, BMA and biopsy,
Cytogenetics and flow cytometry (PNH)