Professional Documents
Culture Documents
SCIENCE
The PHILOSOPHY OF SCIENCE
investigates philosophical
assumptions, foundations, and
implications of the sciences
SCIENCE
WHAT IS SCIENCE?
SCIENCE
- systematic search for
knowledge
- aim (knowledge), an activity
(search),and with certain
qualifications (systematic)
SCIENTIFIC RESEARCH
systematic and socially organized
a.Search for
b.Acquisition of
c.Use or application of knowledge and
insight
DIFFERENTIATING
SCIENCE FROM
NONSCIENCE
DIFFERENTIATING SCIENCE FROM NONSCIENCE
3. PRAGMATIC THEORY OF
TRUTH
- the truth is what is useful or
what works
WHY MOST RESEARCH RESULTS IN EMERGING FIELDS ARE
FALSE
1.The studies conducted in an emerging scientific field are
small
2.The effect sizes in an emerging scientific field are small
3.The number of tested relationships is great but the selection
of tested relationships is small
4.The flexibility in designs, definitions, outcomes and analytical
modes in an emerging scientific field are great
5.The financial and other interests and prejudices in a scientific
field are great
6.The scientific field is hot (more scientific teams are involved)
CAUSATION
The causes of phenomena
1.Necessary Condition
2.Sufficient Condition
3.Combination of conditions that together are
sufficient/Insufficient and Necessary part of an
Unnecessary but Sufficient condition (INUS)
PROBABILISTIC CAUSATION
1.STRENGTH OF ASSOCIATION
The stronger the association, the less
likely the relationship is due to chance
or confounding variable
BRADFORD HILL’S “VIEWPOINTS” ON
CAUSATION
3. SPECIFICITY
if an association is limited to specific
persons, sites and types of disease, and if
there’s no association between the
exposure and other modes of dying , then
the relationship supports causation.
BRADFORD HILL’S “VIEWPOINTS” ON
CAUSATION
4. TEMPORALITY
the exposure of interest must
precede the outcome by a period of
time consistent with any proposed
biologic mechanism
BRADFORD HILL’S “VIEWPOINTS” ON
CAUSATION
5. BIOLOGIC GRADIENT
there is a gradient of risk associated
with the degree of exposure
BRADFORD HILL’S “VIEWPOINTS” ON
CAUSATION
6. BIOLOGIC PLAUSIBILITY
there is a known or postulated
mechanism by which the exposure
might reasonably alter the risk of
developing the disease
BRADFORD HILL’S “VIEWPOINTS” ON
CAUSATION
7. COHERENCE
the observed data should not
conflict with known facts about the
natural history and biology of the
disease
BRADFORD HILL’S “VIEWPOINTS” ON
CAUSATION
8. EXPERIMENT
the strongest support for causation
may be obtained through controlled
experiments
BRADFORD HILL’S “VIEWPOINTS” ON
CAUSATION
9. ANALOGY
in some cases, it is fair to judge
cause-effect relationships by analogy
COUNTERFACTUAL
CONDITIONS