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Presentation Outline
• Biopotentials
• Electrocardiogram, ECG
• ECG characteristics
Muscle Reaction
Resting State
Biopotentials from Cells
Electrical Signals From the Body
Left Heart
Contracts
Electrodes Convert
Ionic Signals From The Body DIAGNOSTIC
Into Electrical Signals in Wires MONITOR
ECG
BP
TEMP
RESP
Na+ e-
K+ e-
Cl - e-
Basic ECG electrode connections
Electrocardiogram
Records Electrical
ECG is Measure Changes From Beating
of Heart as a Heart
Ionic or Electrical Vin- INA
(Left Arm)
Generator
+2.5V dc Vin = Vin+ - Vin-
ECG +2.5V dc
Heart
+2.5V
Vin+ INA
(Right Arm)
+2.5V
Electrodes Transduce
Elec
Ions Into Electrons
+2.5V dc
Common-mode Volt
= (Vin+ + Vin-)/2
(Used for RL Drive)
ECG Einthoven Triangle, 1907
3 Derived Leads
I, II, III Einthoven’s Law
RL
Ref
ECG Electrode – Electrical Model
0 to 500mV Electrode
0.5 to 10F
0.5 to 100k Skin Amplifier
1k 1F
Body
55 10k
10kΩ 10^10
1k 1F
R
1 mV p-p ECG signal has faster rise
P TU
100Hz BW, 70 harmonics
QS Left Heart Relaxes
Left Heart Contracts
Actual ECG - Normal
S
= BW
“Mr. E. C. Gee”
ECG
Vin- INA
(Left Arm)
Demo Meter
0 6 0
Heart
About 1mVp-p
Board BPM
Vin+ INA
Single +5V Supply
(Right Arm)
ECG BP
Vin- INA
(Left Arm)
Meter
Finger
INA & Vout Cardiotach 6 0
0.15 – 2.5mVp-p
0
OPAs Circuit BPM
Heart
Vin+ INA
(Right Arm)
Vout, Overall
Non-Inv Gain
With Respect
to Vin- INA
(Right Leg)
Normal-Mode dc Normal-Mode dc
R Removed
480R
R1 22pF
390k R4 1k C2
Vin-
480mV max dc differential (Left Arm)
R6 C1 2
electrode potential Vin = Vin+ - Vin- 40.2k100pF 1
-
+2.5V dc U1
0.15 - 2.4mVp-p 8 INA326
40.2k 3
R7 +
Heart +2.5V dc R2
390k R51k
Vin+
(Right Arm) +5V 0.1uF
C3
22pF RG =R6+R7
2 - 8Cb2 Vcm +
A1 1
3
+ 4
U2 47pF C4
OPA2335 R8
R9 20k
390k
Self-Zero
+2.5V dc 6
390k 7 -
A2
Common-mode Volt R3 Vcm - + +2.5
= (Vin+ + Vin-)/2 5
(Used for RL Drive) (high inverting gain)
Right Leg Drive Amplifier
A Precision Low-Level DAS/ECG
Cardiotachometer Demo Board
CMOS +5V SINGLE SUPPLY, INA326/7 & OPA2335
INA326,
7 x4k R16 1.24k
A3
81
R18
Vout
x6k R17 0.825k = Vin x Rgain total
327 (shtdn) 6 Vout INA 3 + 4 0.1uF
R/R I/O
ac
High Pass Filters Cb3 0.15V to 4.8Vp-p out
Self-Zero (dc restoration)
Hold
5 4C5 R11 R12 R13
R10
470pF 3.01M 316k 80.6k
200k
0.05Hz 0.5Hz 2Hz (quick restore)
ac 20k
dc + 5 +2.5V
7 +5V supply
A4 U3 Vdc R19
- 20k
C6 6 OPA2335 pedestal R20
C high pass = 1uF Self-Zero ½ Vsup
Integrator (high pass filter): Electrically Isolated
Time Constant = RC. Fo=
0.05Hz diagnostic mode, from Earth Gnd
0.5Hz monitor mode, and
+2.5V dc 2Hz quick restore
Power Supply
ac-Coupled
Analog Circuit Common
Removes dc electrode offset
(isolated from earth ground)
+Vs -Vs
A Precision Low-Level DAS/ECG
Cardiotachometer Demo Board
DC restorer - removes electrode offset
R1 + Ref
+
R2
C2 1uF R2 3M
+5
C1 470pF
f
R1 200k
0.05Hz
-
2.5v R4 20k
+
+ +5
U2 OPA365
+5 R3 20k
A Precision Low-Level DAS/ECG
Cardiotachometer Demo Board
Light Sound
Flash Burst
Front-End
Meter
ECG (Electro)
Differentiator
One Shot Flasher
Or Peak-to-Peak
Multivibrator
Detector Beep
BP (Optical)
oscillator
See Detailed Circuits
A Precision Low-Level DAS/ECG
Cardiotachometer Demo Board
+5V Single Supply
Front-End
<30 to >240 Beats per Minute
ECG Differentiator & Pos-Neg Burst Output
+2.5V
Peak-to-Peak Detector One Shot fosc = 1.44 / C15 (R26 + 2R27) 1kHz
+5V
+2.5V Pulse Stretcher 0V
50% osc duty cycle
Person +5V
TON = 1.1R25C13 = 0.1s thi = 0.693 C15 (R26+R27), tlo = 0.693 C15 R26
Vout Elec Common
D2 0.1uF
C10
6 0.01F 0.01F
IN4148 R25 C12 Cb6 R26 C14
+5V 7 1M 3 4 14 28k 11
0.1F 2 5
8 D1 R22 9
0.1uF
Cb4
1 5 2M 1
½ TLC556 R27 13 ½ TLC556 R28 R29
C11 61.9k
3 4 IN4148
3.01M 0.1F 2 Dual Timer 12
Dual Timer 4.99k 249
R19 R20 C16
R21 8
20k 20k OPA2335 0.1F 0.01F 1F
U4 C13
One-Shot C15
Oscillator
+5V 6 Trig 5 10 Reset
0.1uF
R24
100k
100msec 1kHz
Cb5 U6
2 +5V R23 Clean 7
8 1 10k 6 Triggering
7
3 4 OPA2335 +5V +5V
U5 5 LED Speaker
0V 0V
Vdcpedestal = +2.5V = ½ Vsup
A Precision Low-Level DAS/ECG
Cardiotachometer Demo Board
Battery, Power Sub-Regulator
and Auto Power Down Circuit
<1mA to 15mA On
6A Off
Battery +6.5V to +9.25V +5.9V to +8.65V
Reg Output Power Down When C3
D3 4 4A Iq is Charged >90% of Vreg
0.6V Drop
Ext. Reverse TPS 71550
External i
bat protect 5V Vreg +5V
Supply +4.8V
+5.1V to LDO Reg
+24V Cb7 SOT323-5 5 10M +5V 1A U8 1.2A
R30 +4.5V
+ C17
SC70 0A e 1M Iq +1mA to
0.1F R31 4 5 +15mA
9V Cb8
-
U7 2 C18
R33
TLV 3491 1
Battery 0.47F 1k
+4.5V Comp
- C19
dc sot23-5
100F + 2
Load
3 1M
C3 4.75M
R32
R34
Speaker On
Left Thumb
G = 1kV/V
OPT Not Used
In This Example 0.05Hz to 35Hz BW
Plugged Into
ac-Coupled
Position
Right Thumb
Forward, Out put Swing Up From
Mid +2.5Vdc Towards +5V
Right Finger
Underneath
ac-coupled ECG Waveform Appear at Vout
A Precision Low-Level DAS/ECG
Cardiotachometer Demo Board – top side
Gain Control, Selected By Changing Shorting Bar Position
LA
LED
Input
40 Vsup
Gain minute Ext
x1k,2k,4k,6k Timer
Start Off/On
Input Pins
Ext Switch
Speaker
Vout
ac LPF
dc 17,35,100Hz
RA HPF Ext +5V
Input dc,0.05,0.5,2Hz Com
RL
back
A Precision Low-Level DAS/ECG
Cardiotachometer Demo Board – top side
Vout
Gain LPF
x1k,2k,4k, 17,35,100Hz,
HPF 6k,Ext Ext
OPA U2 ac 0.05,0.5,
dc Breadboard
CM 2Hz
Sel Area
Right Arm Pad, Vcm, +, -, or 3 R Div Can Convert Instrumentation U1 OPA U3 2nd +5V LDO U7 Speaker
Vin+ of IA Com Select Single-ended to Diff Amplifier 1st Stage Gain Stage Gain TPS71550
A Precision Low-Level DAS/ECG
Cardiotachometer Demo Board – back side
This Demo Board Supports Many Applications Brief Instructions
Easy-to-Use Pin
Sockets (No Soldering)
Area
Low-Level DAS / ECG Cardiotachometer
Demo Board - Standing
Gently Hold Electrode Pad Areas (relax fingers), Standing can be ok. Sit Down if Possible
A Precision Low-Level DAS/ECG
Cardiotachometer Demo Board
Additional Applications
Vref
Puffing
Tube
Pressure
ac-Coupled
Puffing Pressure
Input
Same Phase
Mechanical
Pressure Gage
Low-Level DAS / ECG Cardiotachometer
Demo Board – Puffing Pressure Bridge
0.2 second per puff
300 puffs per minute
SIGNAL
1.5Vp-p ac
+2.5V
Offset
0.2 second
Puffs
Scope
Trace 0V
+4V
2nd Timer 0V
100ms, 1kHz
Burst Osc Out
A Precision Low-Level DAS/ECG
Cardiotachometer Demo Board
Squeezing Vref
Circuit Uses OPA336s
Tube Instead of OPA335s
dc-Coupled
Pressure Bridge Slowly Squeezing
Tube Opposite
Pressure Tubing
T-Connection
Phase
Low-Level DAS / ECG Cardiotachometer
Demo Board – Squeezing Pressure Bridge
Scope
Trace
#1 +5V on Bridge SIGNAL, with +5V Bridge Excitation
0.99V 0.99V out G=100 = 9.9mV in => 0.255psi bridge
#2 +2.5V on Bridge
0.51V SIGNAL, with +2.5V Bridge Excitation
0.51V out G=100 = 5.1mV in => 0.495psi bridge
Half signal 5 seconds
amplitude,
due to half Vdc offset + Vac sig
43mV + 0.99V
2nd Timer
excitation 0V 100ms, 1kHz
voltage Slow Squeeze
Burst Osc Out
Pulse +4V
Triggered P-P Detector
0V
A Precision Low-Level DAS/ECG Cardiotachometer
Demo Board - Optical Relative Blood Pressure Monitor
390k 20k
Gt=6kV/V
17Hz
2Hz
ac-
Coupled
SIGNAL
0.7Vp-p ac
Optical
+2.5V
1st Timer Offset
Trigger
0.94 second
Input Scope 0V
Trace
1st Timer
Output
0V
2nd Timer
100ms,
1kHz Burst 0V
Osc Out Missing Sound Burst
Did Not Trigger P-P Detector or Maybe
DIGITAL O-SCOPE Abnormality
A Precision Low-Level DAS/ECG
Cardiotachometer Demo Board