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Ide, T. et al
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BACKGROUND
BACKGROUND
It has recently
Chronic hepatitis C
virus (HCV) been reported
infection is a major that the HCV SVR
cause of liver induced by DAA
cirrhosis and treatment
hepatocellular reduced the
carcinoma (HCC) OBJECTIVE incidence of HCC
To clarify whether
DAAs have a
favorable effect on
Recently, IFN-free suppressing the
development of However, increases
direct-acting antiviral
agents (DAAs) have HCC in unexpected early
been developed, occurrence or
resulting in high rates recurrence of HCC
of sustained virological after HCV
response (SVR) in elimination by
patients with HCV DAAs have also
been reported
PATIENTS AND METHOD
Method
According to the
multivariate analysis,
sex (male), age, FIB-4
index, and GGTP were
independent factors
significantly associated
with HCC
Patients with 4
risk factors
have a higher
incidence than
patients with 3
or 2 or no risk
factors
Time of HHC diagnosis from DAA treatment initiation
and the maximum HCC diameter at diagnosis
Old Age
Risk Factor Wang et al, suggested that
GGTP was associated with DNA
High GGTP damage, genomic instability,
and genetic mutation by
increasing the uptake of iron,
leading to the progression of
High FIB-4 HCC
Weakness Our Study
Accurate comparison of
HCC occurrence rates
requires comparison with
the rate in patients not
receiving treatment;
however, it is not
ethically possible to
conduct such a study.
CONCLUSION
The results of this However, HCC
prospective study development still occurs.
suggested that achieving Careful follow-up is
SVR by DAA treatment important in patients with
reduces the incidence of risk factors.
HCC
Old age, male sex, high Patients with large and early
serum GGTP level, and tumor occurrence did not
receive sufficient diagnostic
high FIB-4 index were
imaging. We recommend
important risk factors to enhanced abdominal CT or MRI
predict the occurrence of before treatment with DAAs is
HCC. initiated.
TERIMA KASIH