CERVICAL CANCER

• ASHISH S.BHILANGE • TASMIYA KAUSAR

SK.
INTRODUCTION
According to National Cancer Institute Cervical cancer is the
cancer that forms in the tissues of the cervix.
It is the malignant tumor of the cervix,the lowermost part of the
uterus.
ETIOLOGY
• Primary underlying cause of cervical cancer is the
infection with Human Papilloma Virus ,mostly due to
sexual contact.
• It usually takes 10-20 years from precursor lesion caused
by HPV to develop into invasive cancer.
• It produces an array of infections ranging from benign
warts to malignant neoplasia of cervix.
WHAT IS HPV?
• Human papilloma virus belongs the family
Papillomaviridae.
• It has selective tropism for human epithelium of skin and
mucus membrane.
• Non-enveloped, size:50-55nm with icosahedral capsids
composed of 72 capsomeres.
Viral Genome of HPV
• HPV consistes of doubble stranded circular DNA of
7900-8000 bp.
• It consists of:
I. Early region[E]
II. Late region[L]
III. Non-coding regulatory
protiens
MOLECULAR MECHANISM
PATHOGENESIS
 TYPES

Sq.cell Neuroendocrin
Adenocarcino Adenosqamous
carcinoma e
PREVALANCE
• Cervical cancer is the commonest cause of death among
women in develoing country
• WORLDWDE- HPV is asso.with 50,000 new cases of CC
& 250,000 asso.with cervical cancer death.
• every year in INDIA 1,22,844 women are diagnosed with
cervical cancer & 67,477 dies from it,.

• In MAHARASTRA high risk of HPV was asso. With low

education,early age at first sexual intercourse.
•
RISK FACTOR
• Sexual contact
A women has higher risk of developing cervical cancer
If she —
 Has had multiple sexual partner .
 Having sexual relation before age 18yr
Unprotected sex
Smoking
 Family histroy
Weakened immune systeam.
.
TREATMENT
• Treament for cervical cancer depends upon the stage of
the cancer.
• Treatments include:
Surgery-Hysterectomy, Cervicectomy, Cryosurgery and
Lymph node dissection
Chemotherapy
Radiation therapy
PREVENTION
• Vaccination against HPV- recommended for all boys and
girls by age 11-12 years,as well as young men and
women upto 26 years.
FDA licensed vaccines:1] Nine valent vaccine(Gardasil)
2] Bivalent vaccine(Cervarix)
• Barrier methods of contraception can block sexual
transmission , thus prevent anogenital HPV infections.
• Avoid multiple sexual partners.
CONCLUSION
• Lack of knowledge and awareness of HPV Infection ,risk
factor .
• PREVENTION-
• HPV education
• Screening for early detection
• Encourage follow up session
• VACCINATION-
• National programs –health promotion campaign on local &
national basis.
• Lower cost or free vaccination.
• Develop public heath national screening programme