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Dengue is always a diagnosis of exclusion, and other diseases with the same initial clinical
presentation must be suspected. In order to help the clinician in the detection of severe forms of
dengue (DHF/DSS), even when the definitive diagnosis has not been made yet, the following three
essential laboratory tests may help in the evaluation of the real clinical conditions of the patient and
its early supportive management:
Advanced . . . . .
• Total White Blood Cells Count: In case of dengue, this test will reveal leukopenia. The presence of
leukocytosis and neutrophilia excludes the possibility of dengue and bacterial infections
(leptospirosis, meningoencephalitis, septicemy, pielonephritis etc.) must be considered.
• Thrombocytopenia (less than 100.000 per mm3): Total platelets count must be obtained in every
patient with symptoms suggestive of dengue for three or more days of presentation. Leptospirosis,
measles, rubella, meningococcemia and septicemy may also course with thrombocytopenia
• Hematocrit (micro-hematocrit): According to the definition of DHF, it’s necessary the presence of
hemoconcentration (hematocrit elevated by more than 20%); when it’s not possible to know the
previous value of hematocrit, we must regard as significantly elevated the results more than 45%.
Medication of DHF
• Medication Summary
• No specific antiviral medication is currently available to treat dengue. The treatment of
dengue fever is symptomatic and supportive in nature. Bed rest and mild analgesic-
antipyretic therapy are often helpful in relieving lethargy, malaise, and fever
associated with the disease. Acetaminophen (paracetamol) is recommended for
treatment of pain and fever. Aspirin, other salicylates, and nonsteroidal anti-
inflammatory drugs (NSAIDs) should be avoided.
• Patients with dengue hemorrhagic fever or dengue shock syndrome may require
intravenous volume replacement. Plasma volume expanders can be used in patients
who do not respond to isotonic fluids
Thanks for the attention guysss