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Solvent Compatibility of Poly(dimethylsiloxane) -Based

Microfluidic Devices
excellent solubility
3
1. Cohesive energy density 𝑐 (𝑐𝑎𝑙/𝑐𝑚 ), intermolecular 7.3 < δ < 7.5
attractive interactions within a unit volume of material
𝑐 = −𝑈𝑀/𝑉M
- c must be similar high solubility

Increasing swelling ability


7.3 < δ < 9.5
2. Solubility parameter (Hildebrand value) δ = 𝑐 1/2 slightly polar
δ (PDMS) = 7.3 𝒄𝒂𝒍𝟏/𝟐 𝒄𝒎−𝟑/𝟐
moderate solubility
- similar δ parameters 9.1 < δ < 11.3
0.46 < μ < 2.78
3. Dipole moment of the solvent μ(D)
-polar contributions
μ (PDMS) = ~ (0.6 - 0.9) D

- non-polar solvents

Anal. Chem. 2003, 75, 6544-6554


Hazard of solvents
Flammability Health Instability/reactivity
diisopropylamine
3 2 1
dipropylamine
3 2 1
triethylamine
3 3 0
pentanes
4 1 0
hexanes
1 3 0
n-heptane
3 1 0
cyclohexane
3 1 0
xylenes
3 2 0
toluene
3 2 0
chloroform
0 2 0
trichloroethylene
1 2 0
diethyl ether
4 1 1
dimethoxyethane (DME)
2 2 0
tetrahydrofuran (THF)
3 2 1
Hazard of solvents
Flammability Health Instability/reactivity
diisopropylamine
3 2 1
dipropylamine
3 2 1
triethylamine
3 3 0
pentanes
4 1 0
hexanes
1 3 0 Blue fibers
n-heptane
3 1 0
cyclohexane
3 1 0
xylenes
3 2 0
toluene
3 2 0
chloroform
0 2 0
trichloroethylene
1 2 0
diethyl ether
4 1 1
dimethoxyethane (DME)
2 2 0
tetrahydrofuran (THF)
3 2 1

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