Introduction

• Asthma is a heterogeneous disease comprising

several sub-phenotypes with different clinical,
inflammatory and functional characteristics
• As adult-onset asthma covers more than 50%
of new diagnoses of asthma
• This is a clinically important phenotype. Adult-
onset asthma is associated with more
(persistent) eosinophilic airway inflammation
and more chronic sinus disease
 Introduction
• In this study, we hypothesised that patients
with adult-onset asthma at risk of an
accelerated decline in lung function can be
identified at diagnosis. The aim of this study
was to identify clinical, functional or
inflammatory risk factors of accelerated FEV1
decline in a prospective 5-year study in adults
with newly diagnosed asthma.
 Methods
Subjects
 Methods
Study design
 Methods
Study measurements
 Methods
Definition of accelerated decline