which there is a necrosis and inflammation of the liver cells. VIRAL HEPATITIS To date, five definitive types of viral hepatitis have been identified: hepatitis A, B, C, D, and E. VIRAL HEPATITIS Hepatitis A and E are similar in mode of transmission (fecal-oral route) whereas Hepatitis B, C, and D share many other characteristics. Hepatitis A Hepatitis A Hepatitis A is a liver disease caused by Hepatitis A virus (HAV) It is formerly called infectious hepatitis. It is caused by an RNA virus of the Enterovirus family. TRANSMISSION Fecal-oral The virus is primarily spread when an uninfected and unvaccinated person ingests food or water that is contaminated with the feces of an infected person TRANSMISSION Sexual activity This is more likely with oral-anal contact or anal intercourse with multiple sex partners prevalence Countries with overcrowding and poor sanitation A child or young-adult can acquire the infection at school through poor hygiene, hand-to-mouth contact, or close contact during play. prevalence Virus is then carried home where haphazard sanitary habits can spread it through the family. Risk factors Poor sanitation Lack of safe water Use of recreational drugs Living in a household with an infected person Risk factors Being a sexual partner of someone with acute Hepatitis A infection Travelling to areas of high endemicity without being immunized Incubation period The incubation period is estimated to be between 2 to 6 weeks with mean of approximately 4 weeks. Clinical manifestations Many patients are anicteric (without jaundice) and symptomless Mild, flulike upper respiratory tract infection Low grade fever Severe anorexia Clinical manifestations Jaundice Dark urine Indigestion ( nausea, heartburn, flatulence) Strong aversion to taste of cigarettes smoke or other strong odors Clinical manifestations Symptoms tend to clear as soon as the jaundice reaches its peak, perhaps 10 days after its initial appearance Assessment and diagnostic findings Liver and spleen are often moderately enlarged for a few weeks after onset Hepatitis A Antigen may be found in stool Assessment and diagnostic findings HAV antibodies are detectable in the serum PREVENTION Scrupulous handwashing Safe water supplies Proper control of sewage disposal Effective (95% to 100% after two to three doses) and safe HAV vaccines include Havrix and Vaqta. PREVENTION Immune globulin is recommended for household members and sexual contact of people with hepatitis A. It can also be given intramuscularly to those who have not been previously vaccinated during incubation period MEDICAL MANAGEMENT Bed rest Nutritious diet (cereals & grains, vegetables & fruits, dairy products and proteins from fish and eggs) During period of Anorexia, give small frequent feeding with IV fluids with glucose. MEDICAL MANAGEMENT Gradual but progressive ambulation NURSING MANAGEMENT Give patient and family specific guidelines about Diet Rest Follow-up blood work Avoidance of alcohol Sanitation and hygiene measures NURSING MANAGEMENT Hand washing after bowel movement and before eating Environmental sanitation Hepatitis B Hepatitis b Unlike HAV, the Hepatitis B Virus (HBV) is transmitted primarily through blood. It can be found in: Blood Saliva Semen Vaginal Secretions Hepatitis b It can be transmitted through: Mucous membranes Breaks in the skin Mother through infants but not via the umbilical vein Hepatitis b HB is a DNA virus composed of the following antigenic particles: HBcAg – hepatitis B core antigen HBsAg – hepatitis B surface antigen HBeAg – an independent protein circulating in the blood Hepatitis b HBxAg – gene product of X gene HBV DNA Hepatitis b Each antigen elicits its specific antibody and is a marker for different stages of the disease process: Anti- HBc – antibody to core antigen of HBV Anti-HBs – antibody to surface determinants on HBV Hepatitis b Anti- HBe – antibody to hepatitis B e-antigen Anti-HBxg – antibody to the hepatitis B x-antigen Incubation period HBV has a long incubation period. (1 to 6 months) It replicates in the liver and remains in the serum for relatively long periods. Risk factors Frequent exposure to blood, blood products or other body fluids Health care workers Hemodialysis Male homeosexual and bisexual activity IV/injection drug use Risk factors Close contact with carrier with HBV Travel to or residence in area with uncertain sanitary conditions Multiple sex partners Recent history STD Receipt of blood or blood products Clinical manifestations Rashes Loss of apetite Dyspepsia Abdominal pain Generalized aching Malaise Weakness Clinical manifestations Jaundice may or may not be present, but if it occurs, light-colored stools and dark urine may accompany it. Liver may be tender and enlarged to 12 to 14cm vertically. prevention Preventing transmission Continued screening of blood donors Disposable syringes, needles and lancets Good personal hygiene Gloves should be worn when handling blood and body fluids prevention Eating and smoking is prohibited in the laboratory and in other areas exposed to secretions, blood or blood products. Patient education prevention Active immunization It is recommended for people who are at high risk for Hepatitis B Recombivax HB – a yeast- recombinant vaccine Booster are recommended for people who are immunocompromised prevention A hepatitis B vaccine prepared from plasma of humans chronically infected with HBV is used only rarely in patients who are immunodeficient or allergic to recombinant yeast-derived vaccines prevention Both forms of Hepatitis B vaccine are administered intramuscularly in three doses. prevention Passive Immunity Hepatitis B Immune Globulin (HBIG) provides passive immunity to hepatitis B and is indicated for people exposed to HBV who have never had hepatitis B and never received hepatitis B vaccine. prevention Indications for HBIG Inadvertent exposure to to HBAg- positive blood through percutaneous or transmucosal routes Sexual contact with people positive for HBAg prevention Perinatal exposure MEDICAL MANAGEMENT Alpha-interferon Side effects: fever, chills, anorexia, nausea and fatigue Lamivudine (Epivir) and Adefovir (Hepresa) MEDICAL MANAGEMENT Bed rest then gradually increased activity Adequate nutrition (Proteins are restricted Antacids and antiemetics Nursing management Assist patient in gradual resumption of physical activity Nurse identifies psychosocial issues and concerns Minimize social isolations Reduce fears and anxieties Nursing management Avoid sexual contact, hygiene, alcohol. Hepatitis C
a viral infection that causes
liver inflammation, sometimes leading to serious liver damage The hepatitis C virus (HCV) spreads through contaminated blood. Symptoms Bruising easily Fatigue Poor appetite Yellow discoloration of the skin and eyes (jaundice) Dark-colored urine Itchy skin Fluid buildup in your abdomen (ascites) Swelling in your legs Weight loss Confusion, drowsiness and slurred speech (hepatic encephalopathy) Spider-like blood vessels on your skin (spider