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forPh.D.,
E. A. Jewell-Motz, Ph.D., J. R. Kaczvinsky, Skin K. MCare
. Lammers, M.S., S. Xie, Ph.D., R. M. Osborne, Ph.D
P&GBeauty, Cincinnati, OhioUSA
AQP3 Signal
0.9
1990’s (1), there are now 13 distinct AQP 0.8 expression and glycerol transport
family members that have been identified in
5000 Control 100uM
0.6
Studies activity of AQP3 as determined in
a variety of mammalian tissues, many of * vitro.
-tx
e
in
EE
EE
EE
differentiation (5), both critical processes for biopsy relief, urinary incontinence, or relief for
st
el
Caffeine Stimulates AQP3
po
as
• AQP RNA expression quantitated via
3
B
maintaining skin hydration, barrier function diarrhea.
2d
GeneChip™ assay Activity in vitro
and overall skin health.
References
Objective 130
120
1. Preston G. M., Carroll T.P., Guggino W. P. and
Agre P., Science 256, 385-387 (1992).
Glycerol Transport
Clinical Design
% Increase in
110 ●40 female subjects 2. Sougrat R., Morand M., Gondran C., Barre P.,
● Identify compounds that stimulate 100
●4 test sites per leg (8 total per subject), 5x4 cm2 area, Gobin R., Bonte F., Dumas M., and Verbavatz
aquaporin-3 expression and activity in skin 2 ul/cm2, total 40 ul treatment twice/day except
J., J. Invest. Derm., 118(4), 678-685 (2002).
cells. weekends- 1x per day
3. Sugiyama Y., Ota Y., Hara M., and Inoue S.,
90