Professional Documents
Culture Documents
Dr.Sudipta Bera
PDT(Mch Plastic Surgery)
SSKM & IPGMER
Mechanism of Bone repair
1. Primary bone repair
2. Secondary (callus) bone repair
3. Bone remodeling
Osteoinduction:
Osteoconduction :
Osseointegration:
Distraction osteogenesis
4.Creeping substitution
• Osteoinduction:
Process by which undifferentiated pluripotent cells are
stimulated to become cells within the osteoblast lineage.
• Osteoconduction : Ability of a material to serve as a
scaffold on to which bone can attach and grow
• Osseointegration: Stable anchorage between bone and
implant that results in a structural and functional
connection between the two
• Distraction osteogenesis: Formation of new bone from the
gradual separation of osteotomized fronts
• Creeping substitution :Process of graft resorption and
replacement of necrotic bone by vascular ingrowths and
new bone formation,
Variables influencing bone repair
1. Blood supply
2. Age
3. Fracture fixation
4. Local infection, osteomyelitis,irradiation
contracture
Primary bone repair
• Primary bone repair involves the direct
deposition of woven bone by osteoblasts to
re-establish mechanical continuity between
fracture fragments.
• usually accomplished through rigid internal
fixation.
Secondary (callus) bone repair