Presentation on Cefuroxime

Presented by-
Kanij Fatima Koli
Cefuroxime
Cefuroxime is an enteral second-
generation cephalosporin antibiotic. It
is a semisynthetic, broad-spectrum,
cephalosporin antibiotic for parenteral
administration.
Mechanism

Cefuroxime belongs to a class of drugs

called cephalosporin. Cefuroxime, like the
penicillins, is a beta-lactam antibiotic. By
binding to specific penicillin-binding proteins
(PBPs) located inside the bacterial cell wall,
it inhibits the third and last stage of bacterial
cell wall synthesis. Cell lysis is then
mediated by bacterial cell wall autolytic
enzymes such as autolysins; it is possible
that cefuroxime interferes with an autolysin
inhibitor.
use
Cefuroxime is used to treat certain infections caused
by bacteria. They include
 pharyngitis,
 otitis media,
 sinusitis, and
 Bronchitis.
 urinary tract infections,
 gonorrhea,
 Lyme disease and
 impetigo.
SIDE EFFECTS
Cefuroxime oral tablet doesn’t cause drowsiness but it
can cause other side effects. The common side effects
that can occur with use of cefuroxime oral tablet include:
 diarrhea
 nausea
 vomiting
 general feeling of illness or discomfort
 headache
 itching of the vagina or genital area
 pain during sexual intercourse
 rigidity
 sweating
Side Effects (cont.)
 thick, white vaginal discharge with no odor or with a mild odor
 fever,
 chills, or muscle pain.
 Black, tarry stools
 chest pain
 cough
 loose stools
 painful or difficult urination
 shortness of breath
 sore throat
 Kidney problems
 Diaper rash
Side Effects (cont.)
Cefuroxime can cause a severe allergic reaction. Symptoms
can include:
 hives
 trouble breathing
 swelling of your face,
 lips, tongue, or throat.
INTERACTIONS

Cefuroxime may interact with other medications.

Cefuroxime oral tablet can interact with other
medications, vitamins, or herbs you may be taking.
Examples of drugs that can cause interactions with
cefuroxime are -
Oral contraceptives

 drospirenone/ethyinyl estradiol
 levonorgestrel/ethinyl estradiol
 norethindrone acetate/ethinyl estradiol
 desogestrel/ethinyl estradiol
 norgestrel/ethinyl estradiol
Stomach acid drugs
 antacids, such as:
 calcium carbonate
 magnesium hydroxide
 aluminum hydroxide
 H2-antagonists, such as:
 famotidine
 cimetidine
 ranitidine
 proton pump inhibitors, such as:
 lansoprazole
 omeprazole
 pantoprazole
List of some cefuroxime brand
name, and dose in bd
Brand contains Dosage Company name
Name form

AXIM Cefuroxime axetil 12 Suspension Aristo pharma Ltd.

suspension
5mg/5ml
CEFOBAC Cefuroxime axetil Tablet (Film Popular
250mg & Coated) Pharmaceuticals Ltd.
500mg/tablet
CEFOTIL Cefuroxime (as Injection (IV) Square
1.5 IV sodium salt) Pharmaceuticals Ltd.
1.5gm/vial
SEFUROX Cefuroxime axetil Tablet (Film Sanofi-Aventis
125mg, 250mg & Coated) Bangladesh Ltd.
500mg/tablet