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Scenario
Apakah efektif penggunaan probiotik untuk mengatasi
dehidrasi pada diare anak?
Clinical Question
P : infantile
I : Probiotic
C : plasebo
O : reduce dehidration
ANALISIS PICO
P: population/problem I: intervention C: comparison O: outcome
Was the assignments of patients to
treatments randomized ?
Was the randomization concealed?
Were all groups similar at the start of the
trial?
Was follow-up of patients sufficiently long
and complete
Were all patients analyzed in the groups to
which they were randomized?
E 70 A 8B 78
C 58 C 12 D 70
Importancy
CER (control event rate)= d/ (c+d) = 12/(58+12)= 0,17=17%
EER (experimental event rate)= b/ (a+b) = 8/ (70+8) = 0,10-
10%
Baik karena EER< CER
RRR (relative risk reduction) = (CER-EER)/CER = (0,17-
0,10)/0,17 = 41 %
Makin besar RRR makin besar efek terapi
ARR= CER-EER = 0,17-0,10 = 0,07=7%
Makin besar ARR makin besar efek terapi
NNT = 1/ARR = 1/7% = 14
Penghitungan
importancy
95% CI NNT=
= 11,3 %
Is our patient so different from those in the study that its results cannot
apply?
No. the characteristic of the patient in the study is same with our patient.
aged between 6 and
24 months, who suffered from dehydrating acute watery
diarrhoea of less than 3 days duration and had clinical
signs and symptoms of some dehydration (thirst or
eagerness to drink, sunken eyes, dry mouth and tongue and
loss of skin elasticity) were assessed for eligibility (WHO
2006).
Applicability
Is the treatment feasible in our setting?
Conclusion
www.ncbi.nih.gov./pubmed
Dutta, P, et al. (2011). Randomised controlled clinical
trial of Lactobacillus sporogenes (Bacillus coagulans),
used as probiotic in clinical practice, on acute watery
diarrhoea in children.Tropical Medicine and international
health, 2011. May.
Referention