Professional Documents
Culture Documents
Transfusi Darah
Umi S Intansari
TOPICS
Adaptive imm
Innate imm
cells
Lymphoid cells
Resting lymphocytes
are round cells with a
large nucleus
Lymphoid organ
Secondary lymphoid
organs are found
throughout the body.
B cells mature in BM
T cells migrate to
Thymus and
undergo maturation
Blood stream
Thoracic
duct
Lymph nodes
Lymphocytes
recirculate between
blood and lymph
organ until encounter
their Ag
TOPICS
TCR BCR
Dendritic cells catch antigen in the periphery and present it in lymph nodes
Macrophages catch extracelular pathogen
B cells catch soluble antigens in the circulation and presents it in lymph nodes
Antigen Presentation
Phagocytes internalize
pathogens, degrade
them in endosomes
and present the
peptides on MHC II
Th1 Th2
3. Complement system
4. Immunoglobulin
3. Complement system
4. Immunoglobulin
*
Ag binding site
B cells produce antibodies
which can recognize soluble *
antigen
An immunoglobulin molecule
has two identical H-chains
and two identical L-chains
Fc role
1. Proliferation and
maturation: formation of
plasma cells
2. Secretion of antibodies
Repeated stimulation
with the same antigen
increases the antibody
concentration to that
antigen
Immunological memory
Ability of immune system to make second response to same ag more effective & efficiently
TOPICS
1. Components of the immune system
2. Basic principles of innate and adaptive
immunity
3. Complement system
4. Immunoglobulin
Blood
Allogeneic RBC circulation
tranfused,degraded
Uptake by APCs,
Ab production
B cells, presented
to T cell
Red cell alloimmunization
Rh-mothers
Rh- mothersmake
makeanti
antiRh
RhAb
Ab
whenthey
when theyexposed
exposedto
toRh+
Rh+
fetalRBC.
fetal RBC.
MaternalIgG
Maternal IgGantibodies
antibodiesare
are
Transportedacross
Transported acrossthe
theplacenta
placenta
tothe
to thefetus
fetus
IgGanti
IgG antiRh
Rhcoated
coatedthe
thefetal
fetalRBC
RBC
destroyed
destroyedby
byphagocytic
phagocyticcells
cells
Hemolytic
Hemolyticanemia
anemia
mechanism of HLA alloimmunization due to
leukocytes present in platelet transfusion
TOPICS
1. Components of the immune system
3. Complement system
4. Immunoglobulin