BPS - BodyPoweredSenSE

Toward Zero Power Medical Devices

T. Gross (ETHZ LST), C. Hierold (ETHZ MNS), D. Atienza (EPFL ESL),

D. Briand (EPFL SAMLAB), M. Knyazeva (CHUV LREN), G. Wohlrab (KISPI),
P.-A. Farine (EPFL ESPLAB)

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 Early, More Accurate Diagnosis and Intervention
Monitoring using long term multi-modal data capture (EEG)

(ECG)
Alzheimers
Disease,
Dementia, Mild (PEM)
Cognitive
Impairment

Childhood
Epilepsy

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 BodyPoweredSenSE Partners
Micro Nano Systems Academic
and ETH Zurich
Laboratory for Software
Technologies Micro Nano Systems
Laboratory for Software
Technologies
EPFL
KinderSpital ESPLAB
Zurich ESL
SAMLAB
Clinical
CHUV UNIL
KINDERSPITAL
Industry
Exploris
ByElement
Practice for Internal
ESPLAB
Medicine
ESL
3/27/17 SAMLAB
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 BPS - BodyPoweredSenSE
Toward Zero Power Medical Devices

+ TRIBOELECTRIC
+
WEARABLE MEDICAL
DEVICES CLINICAL DATA
ENERGY HARVESTING AND PROCESSING
ENERGY AWARE RUNTIME BIOMARKER
ALGORITHMS AND
 Advances in biomarkers for Cognitive Impairment CHUV LREN
Evolution of Alpha Rhythm (AR) Structure with aging and
cognitive decline
3-component alpha 2-component alpha 1-component alpha
7% 83% 10%

AR structure
in young people

3% 68% 29%

AR structure
in middle-aged people

17% 83%

Mild Cognitive Impairment

(MCI) is an intermediate stage
AR structure between the normal aging and
3/27/17 in MCI dementia 5/15
 Epilepsy Spike Density Assessment for embedded SMART
wearable EEG Sensor Kinder Spital and ETH Zurich
Laboratory for Software Technologies LST

Spike Detection performed on EEG

data recorded from epileptic
children at KISPI
Different algorithms lead to
different diagnostics

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 Kinetic Energy Harvesting from Human Body Movements
EPFL SAMLAB
SAMLAB Stretchable TENGs developed.
Simple design. Different materials. Demonstrated
use of scalable fabrication process.
Performance of PDMS-PTFE & PMDS-PU based
TENGs were comparable. Work as energy
harvester and sensor.

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 Thermal Energy Harvesting from Human Body Heat
Novel Electrodes to gently interface to the skin over long periods
ETH Zurich MNS
Thermal harvesting of human body heat Soft and dry biopotential electrodes
a) b) c)
- Prototype Reference

Lead

Bias +

10m

12 mm

d) e)

8
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 Self powered Active Electrode - EPFL ESPLAB
Heat- Electroencephalogram
Sink
ASIC: Power Converter and EEG (EEG)
readout front-end
Thermoelectric generator
24 electrodes
(TEG) Electrocardiogram
EEG dry electrode (ECG)
Chest Band
Patient
ASIC: Power Converter and EEG readout front-
end (UMC 0.18m)
environment
Power Converter monitoring (PEM)
- High efficiency
TEG
architecture with two
control loops

Electro
de 10-bit 400Hz SAR
Amplifier ADC

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 Emotion Sensing EPFL ESL
Random
Filtering Filtered ECG Classification
Important for Alzheimer: Projection
Lead 1 Random
Agitation DWT Transform
Delineation Projection Diagnosis
Disorientation Fiducial Points (N, V, L, R, A)
Stress
and Epilepsy (specially prediction)
High arousal
Changes in HR and HRV
Multi-signal approach:
ECG
Breathing
Skin conductance
Emotion classification (2D - arousal and valence):
83% in MIT emotion database
84% in Augsburg emotion database
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 Energy Aware Runtime System to optimise trade off between energy available and
medical diagnostic utility
During Design time the MEDICAL
CLINICIANS define the diagnostic
value of different biomarker
algorithms while the SOFTWARE
DEVELOPERS identify the energy
profiles of the algorithms and their
variable configurations. This is defined
in a simple text file for the
RUNTIME to refer to.

The RUNTIME system predicts how much

energy is available for the next few minutes
based on the temperature, ambient light
and the activity of the wearer
It then runs the medical biomarker
algorithm and configuration that adds the
highest marginal utility to the overall
diagnosis thus maximising the benefits to
MEDICAL CLINICIANS for a given
energy harvested
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 Native Systems Group/LST & KISPI
Low power processor and signal conditioning, camera and
sound system - ETH Zurich LST

PEM
Personal Environment Monitor
(Audio/Image)

Audio Recorder Friends Chatting Many voices in a

Prototpye hallway

Camera
Prototpye Facial Capture Human
shapes EEG/ECG
Prototype
3/27/17
fabrication 12/15
 The final Demonstrators chosen to highlight key aspects

6 Electrode EEG fitted into a Cap, with TEG and Solar Power

6 Axis Inertial Sensor with Tribo Electric

ECG fitted into a shirt pocket, with Solar Power Power Source, fitted in shoe sole
3/27/17
Milad Ataei, ESPLAB, EPFL 13/25
 Socio Economic Impact
Socio Medical
The project has significantly contributed to the medical community understanding of the human
brain and how brain rhythms and other biomarkers change as a function of ageing.
To record or process multi-parametric medical data simultaneously from any organ (foot, heart,
brain) over long periods in a comfortable manner, without power interruption or recharge,
Economic
The demonstrators of this project are extremely low-cost devices that can be manufactured as mass
consumer products, thus accessible to the elderly and young for medical monitoring.
Early warning of diseases thereby improving the immediacy and
Assist tuning and efficacy of treatment, and assessment of recovery, while all focusing in the
pharmacological intervention;
One spin off company has emerged and a Next Step project aims towards a second spin off.
Education
The intercourse of so many multidisciplinary PhD students as key research personnel in this project
has underpinned both the strong collaboration between the involved institutions, as well as a
deepening and broadening of the knowledge base of all involved across the multiple levels of
technology and medical science.

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 Thankyou!
From all the BodyPoweredSenSE team

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