INTRODUCTION

TOPIC
 INTRODUCTION
GGT catalyzes the transfer of Gamma glutamyl group from
peptides or peptide like compounds to an acceptor peptide
molecule
GGT acts on peptide or peptide like compunds containing
a terminal glutamate residue joinedto the remained
combined through the terminal gamma-carboxy.
Hepatobiliary type enzyme.
 LOCATION
GGT found in many tissues like highest activity of the
enzyme is found in liver kidneys, bile duct, pancreas,
gallbladder, spleen, heart, brain, and seminal vesicles.
Some enzyme is present in cytosol,but the larger function
is located in cell membrane.
 NORMAL VALUES OF GGT
Normal range of GGT is
for male; 10-50u/l.
for female;7-35u/l.
 FUNCTIONS OF GGT
GGT plays a major role in glutathione metabolism.
Leukotriene synthesis.
Drug
Xenobiotic detoxification.
Resorption of amino acids from glomerular filterate and
from the intestinal lumen.
It is involved in the transfer of amino acids across the cell
membrane.
 CLINICAL SIGNIFICANCE OF GGT
The enzyme present in serum appears to originate
primarily from the hepatobiliary system.
GGT activity is elevated in all forms of liver disease like
obstructive jaundice.
cholangitis
cholecystitis
Biliary atresia
Infectious hepatitis
 CONDITIONS IN WHICH IT IS ELEVATED
Obstructive jaundice
myocardial infarction
alcoholic cirrhosis
pancreatitis
Hepatobiliary obstruction
primary and secondary metastatic neoplasms.
Anticonvulsant drugs
GGT is the most sensitive enzyme indicator of the
hepatobiliary disease.