The Gonzalez Therapy

By Laura Wiseley
Prevalence of Pancreatic Cancer
Fifth leading cause of cancer death
27,000 annual deaths in the U.S.
Overall survival rate
25% at 1 year
10% at 2 years
~4% at 5 years
25% of cases eligible for surgery
Post-op survival <20% at 5 years
Gonzalez Treatment
Enzymes
Porcine Pancreatic Enzymes
Diet
Organic diet, vitamin, mineral, and trace element
supplements, Papaya Plus, extracts of animal origins,
magnesium citrate
Detox
Skin cleansing
Coffee Enemas
Pancreatic Enzymes
From Special Pigs in New Zealand
Clients take up 45 grams
Pancreatic enzymes
Help eliminate toxic waste from body
Help normal cells repair damaged ones
Rationale
Cancer caused by primordial germ cells
Cancer controlled by pancreatic enzymes
Nutrition Program
Organic, not refined, not heavily processed
Nine different diets with 10 variations
Individualized by Autonomic Balance and
Metabolic Type
Sympathetic, Parasympathetic, and Balanced
Genetic Type
Vegetarian, Metabolizer, Meat
Supplements of animal organs, vitamins,
minerals, trace elements, papaya, Mg+ citrate
Skin Cleansing
Further detoxifies body
May be brushing, soaking, or other cleansing
Brushing
On dry skin
Stimulates and cleanses the lymphatic system

Soaking
Help to pull toxins out of the skin
May be done in vinegar or salt and baking soda

Castor oil cleanse

Coffee Enema
Used for ability to stimulate contractions in the
gall bladder
Causes emptying of toxins into the bowel
Historically used in many ancient civilizations
Included in the Merck Manual until 1977
Decaf enemas
Used to prepare for surgery
Some use as a laxative
Coffee Enema
How are they done?
3-4 cups of organic brewed coffee
Cooled to body temperature
Pour into an enema bag
Lay down (recommended)
Hang bag ~18 inches above body
Open valve till coffee reaches surface
Coffee Enema
Insert applicator into
rectum
Open valve to release
coffee into colon
Remove enema bag
Retain enema for 10-20
minutes
Rotate frequently
Scientific Evidence
Mouse Trials
Objective-To examine the effects of PPE on
human xenografts in nude mice
Methods- 30 male mice injected with PC tumor
cells. 15 Given PPE, 15 nothing.
Results-Mice given PPE lived longer (p<.002)
Tumors from PPE mice were smaller
Negative effects of tumors in control mice
earlier and more severe than exp. group
Evaluation of Pancreatic Proteolytic Enzyme Treatment of
Adenocarcinoma of the Pancreas, with Nutrition and
Detoxification Support
Gonzalez NJ, Isaacs LL. Nutrition and Cancer 33 (2): 117-124, 1999

Prospective nonconsecutive case series

11 patients with Stage II or Stage IV PC
No chemo- or radiation therapy, nor
surgical resection
Survival time was the endpoint of study
Mean survival time 25.2 months
Evaluation of Pancreatic Proteolytic Enzyme Treatment of
Adenocarcinoma of the Pancreas, with Nutrition and
Detoxification Support
Gonzalez NJ, Isaacs LL. Nutrition and Cancer 33 (2): 117-124, 1999.

82% survival at 1 year

45% survival at 2 years
36% survival at 3 years
1 patient survived 4 years

How does this compare to chemotherapy?

Gemcitabine Compared with Pancreatic Enzyme Therapy Plus
Specialized Diet (Gonzalez Regimen) in Treating Patients Who
Have Stage II, Stage III, or Stage IV Pancreatic Cancer
Nicholas Gonzalez Clinical Trial

NIH Phase III Clinical Trial

Definition of Phases I, II, III, and IV
Unblinded Intervention Trial
Patients choose either the Nutritional Arm or the
Chemotherapy Arm
Chemotherapy Arm includes tx with Gemcitabine.
QOL assessed at 0, 2, 6, and 12 months
Patients assessed at 1, 3, 5, 7, and 12 months
QOL and assessment done every year after first 12
months.
Gemcitabine Compared with Pancreatic Enzyme Therapy Plus
Specialized Diet (Gonzalez Regimen) in Treating Patients Who
Have Stage II, Stage III, or Stage IV Pancreatic Cancer
Nicholas Gonzalez Clinical Trial

Nutrition Arm (21-day cycle)

Pancreatic Enzymes, Papaya Plus and Magnesium
Citrate
Nutrition Supplementation
Moderate vegetarian metabolizer diet
Coffee enema 2x/d
Daily skin brushing, skin cleansing with castor oil
weekly, salt and soda bath weekly
Complete liver flush and a clean sweep and purge
each month
Conclusions
Present research shows interesting findings
Too small, no control
25 eligible patients were not included
Comorbidities, previous tx, predicted noncompliance
NIH study should give more insight
Diet?
Coffee enemas have not been shown to improve
liver function
Recommendations

Keep your eyes peeled for the NIH study

in the next few years
References
Surac, M. Standop, S. et. al; Pancreatic Enzyme Extract Improves
Survival in Murine Pancreatic Cancer. Pancreas. Vol 28(4), pp. 401-412.
May 2004.
Gonzalez NJ, Isaacs LL. Evaluation of Pancreatic Proteolytic Enzyme
Treatment of Adenocarcinoma of the Pancreas, with Nutrition and
Detoxification Support. Nutrition and Cancer 33 (2): 117-124, 1999
http://nccam.nih.gov/news/19972000/121599.htm
clinicaltrials.gov/show/NCT00003851
www.meb.uni-bonn.de/cancer.gov/CDR0000410719.htm
www.nlm.nih.gov/medlineplus/pancreaticcancer.html
www.dr-gonzalez.com
http://www.ineedcoffee.com/01/01/enema/
http://www.lef.org/magazine/mag2001/aug2001_report_gongalez_01.html