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defficiencies
Phagocytosis
Multiprocess.
Phagocytic system
Composed primarily of
Neutrophils
Eosinophil's
Monocytes
Dendritic cells
Macrophages
Phagocytes
Stages in phagocytosis
Immunodeficency diseases
caused by defects in
phagocytes
Phagocytic dysfuntions:
Dysfunction in:
Phagocyte defect
Conditions:
Eczema(rashes)
skeletal defects
Treatment:
Chediak-Higashi Syndrome
Treatment:
Myeloperoxidase deficency
Clinical features
LAD
Leukocyte
adhesion deficiency
Autosomal recessive
Group of disorders in which the
leukocyte interaction with
vascular endothelium is
disrupted
subunit of integrins
Selectin ligands
Consequences:
Recurrent
Cyclic neutropenia:
Causes:
Neutropenia:
Treatment:
Complement defects
regarding immunodeficency
Complement:
Promotes chemotaxis,opsonization,phagocytosis of
pathogens and bacteriolysis etc
Complement
system:
Complement defects:
Defeciencies in classical
pathway
components(C1q,c1r,C4,C2
,C1-inh)
Alternative pathway
deficiencies(properdin
factor B&D):
MBL deficiency:
Hereditary angioedema:
Autosomal dominant
Deficency of C1 inhibiter
Treatment:
Systemic lupus
erythmatosus: