Professional Documents
Culture Documents
A LS
ANTIFUNGALS
A. Superficial Mycoses
1. Griseofulvin
-PO, Fungistatic
-MOA: Binds to keratin (Protection of the
skin from new infection)
-Increased absorption w/ fatty meal
-USE: Ringworm/Dermatophytes
ANTIFUNGALS
2. Nystatin
-Topical, Polyene antifungal
-MOA: Binds to ergosterol & create holes
USE: Tx of cutaneous/
mucocutaneous candidiasis
ANTIFUNGALS
3. Terbinafine
-Fungicidal
MOA: Inhibition of squalene epoxidase,
accumulation of squalene ergosterol
(toxic to fungal cell)
ANTIFUNGALS
4. AZOLES
MOA: Inhibition of Fungal CYP450
0 Ketoconazole
0 Clotrimazole (Canesten)
0 Ticonazole (Trosin)
0 Miconazole (Daktarin)
0 Fluconazole
0 Itraconazole
ANTIFUNGALS
5. Miscellaneous agents:
0 AP-AP solution Salicylic acid
0 Whitfields ointment salicylic + Benzoic acid
0 Potassium iodide
0 Selenium sulfide (Selsun blue)
-Head and shoulders shampoo (antidandruff)
ANTIFUNGALS
B. Less serious mycoses
1. Ketoconazole First azole introduced to be
used clinically
USE: Cutaneous candidiasis
Antiseborrheic (nizoral)
ANTIFUNGALS
2. FLUCONAZOLE
Tx: Systemic candidiasis
DOC: Cryptococcosis
3. ITRACONAZOLE
-2nd line for less serious mycoses
-2nd line for amphotericin B
ANTIFUNGALS
C. SYSTEMIC MYCOSES
1. Amphotericin B
-grandfather of antifungals
MOA: Binding to ergosterol that results to
formation of pores on the plasma
membrane
USE: Systemic mycoses
Initial tx to reduce fungal burden
Combine w/ flucytosine
ANTIFUNGALS
2. Voriconazole
USE: DOC for Aspergillosis
Tx for Fluconazole resistant Candidiasis
3. Echinocandins (newest)
MOA: Inhibits the synthesis of (1,3)D-glucan,
a
component of the cell wall of fungi
Ex: Caspofungin
ANTIFUNGALS
4. POSACONAZOLE
DOC: Mucomycosis/Zygomycosis
also has an activity against Candida &
Aspergillus
5. Sporotrichosis
occupational disease of gardeners
Tx: Potassium Iodide soln
7. Histoplasmosis
MOT: Bat droppings
CM: Mimics the signs & symptoms of PTB