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GLIAL
Sel2 glial mempunyai fungsi suportif
utk neuron dan prosesus selulernya.
Sel2 ini memp. peranan primer >
reperasi, keseimbangan cairan
& metabolisme energi
Gliomas
Neuronal tumors
Poorly differentiated neoplasms
Meningiomas
GLIOMA
Gliomas derived from glial cells ;
astrocytoma
oligodendroglioma
ependymoma
Astrocytoma
fibrillary astrocytoma 80 % tumor
otak primer dewasa II/IV
anaplastic astrocytoma (III/IV)
glioblastoma (IV/IV).
Clinical Features
Astrocytoma have a tendency to become more anaplastic
with time progress only slowly over a number of years,
with a mean survival of more than 5 years.
anaplastic features and more rapid growth of the tumor.
The prognosis for patients with glioblastoma is very poor.
With current treatment, consisting of resection when
feasible together with radiotherapy and chemotherapy, the
mean length of survival after diagnosis is only 8 to 10
months; fewer than 10% of patients are alive after 2 years.
Oligodendroglioma
5% to 15% of glioma and are most
common in the fourth and fifth
decades.
Patients may have had several years
of neurologic complaints, often
including seizures.
The lesions are found mostly in the
cerebral hemispheres, with a
predilection for white matter.
macroscopic well-circumscribed,
gelatinous, gray masses, often with
cysts, focal hemorrhage, and calcification
Microscopic composed of sheets of
regular cells with spherical nuclei
containing finely granular chromatin
(similar to normal oligodendrocytes)
surrounded by a clear halo of cytoplasm
The most common genetic alterations
in oligodendrogliomas are loss of
heterozygosity for chromosomes 1p
and 19q.
Clinical Features
have a better prognosis than do
patients with astrocytomas
Current treatment with surgery,
chemotherapy, and radiotherapy has
yielded an average survival of 5 to
10 years
Ependymoma
Tumbuh dr lap.ependimal sistem ventrikulus,
termasuk kanalis sentralis medulla spinalis.
Lokasi medulla spinalis (tumors in this
site neurofibromatosis type 2)
microscopic composed of cells with
regular, round to oval nuclei with abundant
granular chromatin. Tumor cells may form
gland-like round or elongated structures
(rosettes, canals) perivascular
pseudorosettes
NEURONAL TUMORS
MENINGIOMA
predominantly benign tumors of adults
usually attached to the dura, that arise
from the meningothelial cell of the
arachnoid.
may be found along any of the
external surfaces of the brain as well as
within the ventricular system, where
they arise from the stromal arachnoid
cells of the choroid plexus
METASTATIC TUMORS
Metastatic lesions, mostly
carcinomas, account for
approximately a quarter to half of
intracranial tumors in hospital
patients. The five most common
primary sites are lung, breast, skin
(melanoma), kidney, and
gastrointestinal tract, accounting
for about 80% of all metastases.
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