Professional Documents
Culture Documents
Introduction
Pituitary
Pulsatility
Cyclicity
Hypophysiotropic or Hypothalamic
Hormones
Peptides & bioactive amines are most common products
of hypothalamus.
Hypothalamic hormones often have multiple actions:
Pituitary Tumors
According to autopsy studies, up to 20% of people harbor
clinically silent pituitary adenomas.
Findings consistent with pituitary tumors are observed in
1030% of normal individuals undergoing MRI exams.
Pituitary tumors account for 91% of lesions from patients
who have undergone transsphenoidal surgery.
Physiologic enlargement of pituitary can be seen during
puberty & pregnancy.
Growth Hormone
Actions of Growth Hormone
Stimulates lipolysis
Prolactin
Characteristics
Prolactin (contd)
Prolactinoma
Prolactin (contd)
Clinical Evaluation of Hyperprolactinemia
Prolactin (contd)
Management of Prolactinoma
Therapeutic goals
Reduce tumor mass
Restore normal gonadal function & fertility
Prevent osteoporosis
Preserve normal pituitary function
Hypopituitarism
Failure of either pituitary or hypothalamus results in loss
of anterior pituitary function:
Hypopituitarism (contd)
Etiology of Hypopituitarism
Lymphocytic hypophysitis
Treatment of Panhypopituitarism