Hodgkin Lymphoma

Disease

Etiology

Hodgkins

unknown;

Lymphoma

Demograph
ics

young
EBV
adults (15infection
34y.o),
may be
older adults
involved in (>55y.o);
pathogenes males; high
is
incidence in
Demograph US and
ics: young
Europe
adults (1534y.o),
older adults
(>55y.o);
males; high
incidence in
US and
Europe.

Clinical
Disease
Manifestati Progressio
ons
m
painless
nodal,

Pathophysi
ology

Microscopic
Appearance

Prognosis

Ig genes of
lymphaden splenic,
Reedopathy,
hepatic,
Sternberg
unexplaine involvemen cells have
d weight
t of marrow undergone
loss, fever, and other
both V(D)J
night
tissues;
recombinati
sweats,
origin:
on and
nodular
germinal
somatic
sclerosis,
hypermutat
splenomeg center or
post
ion;
aly and/or
activation
hepatomeg germinal
of
aly, back or center B
cells;
transcriptio
bone pain
n factor NFKB
Microscopic
appearance
: ReedSternberg
cells;

ReedSternberg
cells;
classical
formlymphohisti
ocytic
variants;
nodular
sclerosis
typedeposition
of collagen
bands;
mixed
cellularity
type-ReedSternberg
cells,
mobonucle
ar variants;

stage I-IIA cure rate:

close to
90%; stage
IV and IVB disease
free
survival at
5yrs is 6070%