Professional Documents
Culture Documents
7%
8%
9%
75%
53%
17%
30%
10%
9%
4%
3%
Alcohol
Iron deficiency
1%
1%
Malignancy
Metastatic carcinoma
Tuberculosis
Hematologic malignancies
Infective endocarditis
Leukemia
Lymphoma
Myeloma
Osteoarthritis
Hypothyroidism
Rheumatoid disease
Protein-energy malnutrition
ACD
Serum iron
Reduced
Reduced
TIBC
Increased
Reduced
Transferrin saturation
Reduced
Normal
Serum ferritin
Reduced
Normal or
Increased
Increased
Normal
High
Low
Sensitivity (%)
Specificity (%)
Likelihood
ratio*
< 200
94
71
3.2
< 45
85
92
11.1
< 15
59
99
54.5
2. Clonal Evolution
- 10-40% develop AML.
- Chromosome abnormalities in 40% of cases
Trisomy 8
5 & 7 deletions (CSFs)
11q23 (MLL gene)
Unproven therapies
Transfusions + desferral administration.
Epo + G-CSF + Danazol.
Experimental therapies
Immune therapies ATG, CSA, Thalidomide
Chemotherapy anti-CD33 Ab, 5-azacytidine