Professional Documents
Culture Documents
By
Wiwik Kusumawati
OBJECTIVE
At the end of this topic the students will
be able to :
1. Explain mechanism of action of both
adsorbents and laxative agents
2. Explain side effects of both adsorbents
and laxative agents
3. Explain indication of both adsorbents and
laxative agents
4. Explain interactions between adsorbents
and other drugs
5. Mention classification of laxative agents
Antidiarrheals
1. Adsorbents
2. Anticholinergics
3. Opiates
Adsorbents
Mechanism of action
Coat the walls of the GI tract
Bind to the causative bacteria or toxin,
Adsorbents
Side Effects
Increased bleeding time
Constipation, dark stools
Confusion, twitching
Hearing loss, tinnitus, metallic taste,
blue gums
Adsorbents
Interaction
Adsorbents decrease the absorption
CONSTIPATION
Abnormally infrequent and difficult
LAXATIVE AGENT
Drugs used for treatment of acute
constipation (drugs accelerating
the passage of food through the
intestine).
A symptomatic therapy which
should not be used chronically
LAXATIVE AGENT
1. Bulk forming
2. Emollient
3. Hyperosmotic
4. Saline
5. Stimulant
Bulk forming
High fiber
Absorbs water to increase bulk
Distends bowel to initiate reflex bowel
activity
Examples:
psyllium (Metamucil)
methylcellulose (Citrucel)
polycarbophil
Emollient
Stool softeners and lubricants
Promote more water and fat in the
stools
Lubricate the fecal material and
intestinal walls
Examples:
Hyperosmotic
Increase fecal water content
Result: bowel distention, increased
peristalsis, and evacuation
Examples:
Saline
Increase osmotic pressure within the
intestinal tract, causing more water
to enter the intestines
Result: bowel distention, increased
peristalsis, and evacuation
Stimulant
Increases peristalsis via intestinal
nerve stimulation
Examples:
castor oil
senna
cascara
bisacodyl
INDICATIONS
Laxative Group
Use
Bulk forming
Emollient
Diverticulosis
Acute and chronic
constipation
Softening of fecal
impaction; facilitation of
BMs in anorectal
conditions
INDICATIONS
Laxative Group
Use
Hyperosmotic
Chronic constipation
Diagnostic and surgical
preps
Constipation
Diagnostic and surgical
preps
Removal of helminths
and parasites
Saline
INDICATIONS
Laxative Group
Use
Stimulant
Acute constipation
Diagnostic and surgical
bowel preps
SIDE EFFECTS
Bulk forming
Impaction
Fluid overload
Emollient
Skin rashes
Decreased absorption of vitamins
Hyperosmotic
Abdominal bloating
Rectal irritation
SIDE EFFECTS
Saline
Nutrient malabsorption
Skin rashes
Gastric irritation
Rectal irritation
Stimulant