Professional Documents
Culture Documents
(18211902)
Scientist
Introduced concept of cellular pathology
Considered father of modern cellular
pathology
Lipofusion
Equilibrium of Cell
Cell injury
Cell death
Cell Injury
Cellular swelling
Cell death
Cellular Swelling
Normal microvilli
Swollen microvilli
Invagination of cell
membrane
Swollen mitochondria,
dilated RER
Loss of intracellular
contact
Regulates flow of
sodium (Na) &
potassium (K) across
membrane
Na+/K+ ATPase pump
requires energy
produced by
mitochondria
Nuclear Changes in
Irreversible Cell Injury
Pyknosis:
condensation
Karyorrhexis:
fragmentation
Karyolysis:
dissolution of
nuclear structure as
result of enzymatic
digestion
Copyright 2012, 2006, 2000, 1996 by Saunders, an imprint of Elsevier Inc.
10
Hypoxia
Anoxia
Microbes
Inflammation
Immune reactions
Genetic & metabolic disorders
11
12
Oxygen Radicals
Hydrogen peroxide
Superoxide
Hydroxyl radical
13
Postperfusion Injury
14
15
Microbial Pathogens
Direct
Indirect
16
17
Cell Adaptations
Atrophy
Hypertrophy
Hyperplasia
Metaplasia
Intracellular accumulation
18
Cellular Adaptations
19
Atrophy
20
Atrophy of Brain
G = gyri, S = sulci
21
Hypertrophy
22
23
24
Hyperplasia
25
Intracellular Accumulations
Exogenous materials
Endogenous metabolites
Hemosiderin
Lipids
26