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Chapter 1, 2
1. Emergent Properties:
Biologists explore life from the
microscopic to the global scale.
New properties emerge with each step
upward in the hierarchy of biological order
Each level of biological organization has
emergent properties The whole is
greater than the sum of its parts
Result from arrangements and interactions
within systems
Systems biology
Study of Biological
Systems
Reductionism:
Reducing complex systems to simpler components
that are easier to study
Examples:
Studies of DNA structure and the Human Genome
Systems Biology:
Seeks to create models of the dynamic behavior of
whole biological systems
Example:
Map of interactions between proteins in a fruit fly cell
Regulatory systems:
Many biological processes are self-regulating
Examples:
1. Water is made up of hydrogen and oxygen atoms.
A mixture of oxygen and hydrogen will not give
you the properties of water.
2. Photosynthesis will only take place in an intact
chloroplasts. Requires chlorophyll and other
chloroplast molecules. Photosynthesis will not take
place in a test tube even if chlorophyll and other
chloroplasts components are mixed in a test tube.
.Both organisms and their environments are affected
by the interactions between them
ecosystem
community
population
organism
organ system
organ
tissue
cell
organelle
molecular
Biosphere
Ecosystem
Community
Population
Organism
Ecologist
Organ system
Organ
Tissues
Cells
Organelle
Molecule
Physiologist
Cell
Biologis
t
Molecular
Biologist
Question:
Can you give specific examples at each
hierarchy level? Atoms, molecules,
organelles, cells, etc.
Arrange the following in the correct the
hierarchy of biological organization, from
least to most complex.
Digestive system, hydrogen, intestinal cell
organelle, protein, intestinal cell, intestinal tissue
Global Warming
Humans have modified our environment
Half the human-generated CO2 stays in
atmosphere and contributes to global
warming
Physiology
Study functions performed by organism
Model organisms
Short generation time
Study of Biological
Systems
Reductionism:
Reducing complex systems to simpler components
that are easier to study
Examples:
Studies of DNA structure and the Human Genome
Systems Biology:
Seeks to create models of the dynamic behavior of
whole biological systems
Example:
Map of interactions between proteins in a fruit fly cell
Regulatory systems:
Many biological processes are self-regulating
Fungi:
Saccharomyces cerevisiae
Model
Organisms
Animals
Bacteria:
Escherichia coli
Fruit fly:
Drosophila melanogaster
Nematode:
Caenorhabditis
elegans
Plants:
Arabadopsis thaliana
Forms of cells
All cells
Are enclosed by a membrane
Use DNA as their genetic information
We will examine,
Cell structure and
organelles
Cell replication
Mitosis
Meiosis
Genomics: Large-Scale
Analysis of DNA Sequences
An organisms genome is its entire set
of genetic instructions
The human genome has
been sequenced
using
DNA-sequencing
machines
Genomics is the study
of sets of
genes within
and between species
7. Feedback Regulation in
Biological Systems
Regulatory systems ensure a dynamic
balance in living systems
Chemical processes catalyzed by
enzymes
Many biological processes are selfregulating: (product regulates the
process)
Negative feedback
Positive feedback
Negative feedback
Positive feedback
Accumulation of product
slows down the process
itself
To achieve homeostasis
Ex. Sweating to
Study of Biological
Systems
Reductionism:
Reducing complex systems to simpler components
that are easier to study
Examples:
Studies of DNA structure and the Human Genome
Systems Biology:
Seeks to create models of the dynamic behavior of
whole biological systems
Example:
Map of interactions between proteins in a fruit fly cell
Regulatory systems:
Many biological processes are self-regulating
8. Evolution to accounts
for lifes unity and diversity
Evolution seeks to give the history of life
as an account of a changing Earth that is
billions of years old
Charles Darwin published On the Origin
of Species by Natural Selection in 1859
Darwin made two main points
1. Species show evidence of descent with
modification from common ancestors
2. Natural selection is mechanism for
descent with modification
Limitations of Science
Limitations of science are set by its
naturalism
Science seeks natural causes for natural
phenomena
Science cannot support or falsify
supernatural explanations, which are
outside the bounds of science
Read:
Chapter 3 The Scientific Enterprise in Biology
Through the Eyes of Faith (by Richard Wright)
What other limitations are pointed out in this
Process of Science
2. Reproducibility
this refers to the confidence we can place
in the experimental data: are our results
reliable?
Question
Does the scarlet king snake benefit from its
mimicry of the eastern coral snake?
Hypothesis
The scarlet king snake avoids predation due to
its mimicry of the eastern coral snake.
Predictions
In areas with both species, predators will avoid
scarlet king snakes; in areas with only scarlet
king snakes, their pattern will have no
protective effect.
Reproducibility: place
hundreds of each kind of
snake.
Results: