Professional Documents
Culture Documents
OBJECTIVES
List the major effects of prostaglandin and
leucotriene
List important sites of synthesis and the effects of
thromboxane and prostacyclin in the vascular
system
List the currently available antagonists of
leucotrienes and prostaglandins and their targets
Explain the different effects of aspirin on
prostaglandin synthesis and on leucotriene
synthesis
OBJECTIVES
Contrast the functions of COX-1 & COX-2
Describe the effects of Aspirin on prostaglandin
synthesis
Contrast the action and toxicity of Aspirin, the
older non selective NSAIDs & COX-2 selective
drugs
List the toxic effect of Aspirin
Describe the effects and the major toxicity of
Acetaminophen
TERMINOLOGY
AINS
NSAID
SAARD
DMARD
Analgesik
Antipiretik
Anti inflamasi
Pain
An unpleasant sensory and emotional
experience associated with actual or
potential tissue damage, or described in
terms of such damage.
Eicosanoid
Klasifikasi : Prostaglandin, Prostasiklin,
Tromboksan, Leukotrien
Mekanisme Kerja : Aktifasi reseptor :
protein G Adenylyl Cyclase (c AMP) /
Phosphatidylinositol cascade ( IP3 & DAG)
Penggunaan Klinis
Obgyn : PGE2 (Dinoprostone), PGF2,
mematangkan Cervix, PGE1 (Misoprostol)
Kontraksi uterus
Pediatry : PGE1 Patent Duktus Arteriosus
Dialysis : PGI2 (Epoprostenol) Hipertensi
Pulmoner
Ulkus Peptikum AINS : Misoprostol
Urology : PGE1 (Alprostadil) Impotensi
Ophthalmology : PGE2 (Latanoprost)
Glaucoma, Unoprostone Meningkatkan out
flow Humor Aqueous
Antagonis Eicosanoid
Kortiko steroid
AINS
Antagonis Leukotrien : Zileuton
Lypoxygenase inhibitor, Leukotrien
receptor antagonist Zafirlukast,
Montelukast
Tricyclic antidepressants
Anitconvulsants
Serotonin reuptake inhibitors
Muscle relaxants
Psychotropic Drugs
Tricyclic Antidepressants
Amitryptiline, Nortryptiline
Anticonvulsant
Tegretol, Dilantin, Gabapentin
Ibuprofen - Advil
Naproxen - Anaprox, Naprosyn
Diclofenac - Voltaren
Indomethacin Indocin
Piroxicam - Feldene
Metamizole - Novalgin
Mefenamic Acid - Ponstan
Ketorolac Tromethamine Toradol
Ketoprofen - Profenid
Celecoxib
Rofecoxib
Nimesulide
Meloxicam
TOKSISITAS
Gastritis
Tinnitus
Prolonged Bleeding Time
Allergy
Reyes syndrome Aspirin
Analgesik Lainnya :
Acetaminophen
Sejak 1893 Paracetamol
Dipakai sebagai analgesik &
antipiretik
Tidak mempunyai efek anti inflamasi
Menghambat PG di sentral
Tidak mengiritasi lambung
Dosis besar hepatotoksik