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Medicine L3
PSL222
Immunity
Lecture 6
Dr. S.Bashir
Lecture objectives
Dr. S.Bashir
Dr. S.Bashir
1. Giardia
2. Influenza
3. Food poisoning.
4. Malaria.
5. Strep throat.
6. AIDS .
7. Tuberculosis.
8. Lyme disease.
9. Hepatitis B.
Dr. S.Bashir
Nonspecific Defenses
Phagocytes
Interferons
Complement
Inflammatory response
Fever
Normal flora.
Dr. S.Bashir
Skin
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Defensive Secretions- 2
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Inflammation
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Complement activation
Activation of
complement acts
through:
1- Direct lysis of
microbial
membranes.
2- Opsonization
of organisms to
facilitate their
phagocytosis.
3- Enhancing the
inflammatory
process.
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Depending on
the site of
maturation of
lymphocytes.
T-lymphocytes
mature in?
B-lymphocyte
mature in?
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Specific immunity
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?What is an Antigen
Antigens are
macromolecules that
elicit an immune
response in the body.
Antigens can be :
-proteins
-polysaccharides
Rarely:
-lipoproteins
- glycolipids.
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Presentation of foreign
antigens
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Classification of acquired
:(specific ) immunity
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Classification of acquired
:(specific ) immunity
Dr. S.Bashir
Thank You
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Physiology: Hematology
Medicine L3
PSL222
Immunity
Lecture 6
Dr. S.Bashir
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Lecture objectives
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MCQ
a. Humoral immunity.
b. Cell mediated
immunity.
c. Acquired immunity.
d. Innate immunity.
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a.
b.
c.
d.
proteins.
Normal flora.
Pyrogens.
Interferons.
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Dr. S.Bashir
Activated
Tlymphocytes
change into
cytotxic cells &
memory cells.
Cytotoxic cells
destroy any
abnormal body
cells, e.g., tumor
cells , cells infected
by a virus or
foreign cells. 31
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Humoral Immunity
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Isotypes of antibodies
:(immunoglobulins)
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Characteristics of Acquired
immune responses
Acquired immunity ( both types) has
several important properties:
1-Specificity.
2- Clonal expansion.
3-Memory.
4- Tolerance of self antigens.
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Specificity-1
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Clonal selection-2
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Clonal selection
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Memory-3
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Memory:
1ry & 2ndry response
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Tolerance-4
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Memory .
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Dr. S.Bashir
:Clinical applications
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Active immunization
Vaccination
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Passive immunization
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Auto-immune diseases
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Causes of Immunodeficiency
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Allergies
Allergies are
excessive and
inappropriate
responses to
(typically)
harmless antigens,
such as the pollen.
Examples :
bronchial asthma,
hay fever. contact
dermatitis
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Mechanism of Allergy
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Thank You
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