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Oncology Nursing: An
Introduction
•
Greek Word
“Karkinoma” for Crab
CANCER
• Proliferation
• Invasion and Metastasis
• Loss of Differentiated Function
• Mutations
The Precise
Etiology of Cancer
is “UNKNOWN”
How does Cancer Develop
Initiation
Promotion
Progressio
n
Defect in Cellular Proliferation
• Under normal situations there is control of
the number of cells in the body.
– Balance between cellular proliferation and
cellular death.
– Contact inhibition
• If something goes wrong in the control
mechanism, it can result in rapid
proliferation of immature cells.
Normal Cells
VS.
Malignant Cells
MITOTIC CELL DIVISION
Normal Cells Malignant Cells
2. Cell birth equals Cell death Cell birth exceeds Cell Death
Stick together in the right place Cancer cells don't stick together
Self destruct if they are damaged May self destruct more slowly than
they reproduce
Become specialized or 'mature‘
Cancer cells don't specialize, but
stay immature
• Atrophy
• Hypertrophy
• Hyperplasia
Reactive & Neoplastic Growth Process
Anaplasia “DeDifferentiation”
• Local spread
• Through the blood
circulation
• Through the
lymphatic system
GENES and MUTATIONS
Normal Genes Mutated Genes
1. proto-oncogene 1. Oncogenes
•A gene that has functions to • A defective gene that is involved
promote cell division. in triggering cancer cell growth
•are responsible for providing the • can cause a cell to divide in an
positive signals that lead to cell unregulated manner.
division. Some proto-oncogenes
work to regulate cell death
2. The loss of function of these
2. Tumor Suppressor genes leads to abnormal cellular
•A gene that functions in the control behavior
of cell division.
•These genes work to limit cell
division and may be contrasted with
oncogenes
FACTS: