Professional Documents
Culture Documents
DNp73 and Stem Cells in Cancer Functional studies of the role of DNp73 and stem cells in Cancer Presentation at Conference Monash Comprehensive Cancer Consortium
Dr Abuds work: to find out relationship between Snai1 and Wnt Signalling in the intestines
LGR5 stain
Therefore:
Snai1 is the master regulator of stem cell populations
more This is when EPITHELIAL cells become more MESENCHYMAL (EMT) After EMT, they can become enterocytes for example.
migratory
Snai1 is involved in EMT (as a regulator) It induces metastasis and maintaining stemness.
Threshold for Wnt: During head-tail embryonic formation, there needs to be a gradient
in level of Wnt expression - Different ways a tissue can respond to Wnt signal; combination of Wnt receptor and inhibitory signals Dickkopf, RNF molecules (inhibit Wnt signals) Rspondins (enhance Wnt signals) - Different processes of development require different thresholds (in different organs) - ANTERIOR POSTERIOR embryonic patterning: head low Wnt and tail high Wnt