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Introduction to Toxicology

Industrial toxicology 2007

Pendahuluan
Systemic poisonings;
Lead : ancient Egypt & Roman times Chemically hazard: 1800s (aniline purple by Perkin) Organic compound Inorganic substances

Industrial toxicology 2007

Industrial toxicology 2007

Science that studies TOXICOLOGY the harmful, or toxic, properties of substances.

Industrial toxicology 2007

All substances have the potential if given in sufficient quantities or under certain circumstances in susceptible individuals to cause harm. There is no clear differentiation between what is considered poisonous and non poisonous to the body. Substances however are general regarded as poisonous if they can cause harm when present in small quantities or in low concentrations.

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TOXICITY (1)
1. The ability of a substance to have an adverse effect on the health or well-being of a human. 2. The level of toxicity depends on QUANTITY or DOSE

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Toxicity (2)
The toxicity of a chemical depends : 1. on the degree of exposure 2. and absorption.

Industrial toxicology 2007

Industrial toxicology 2007

TOXIC EFFECT

Any reversible or irreversible harmful effect on the body as a


result of contact with a substance

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Degree of Hazard
Factors contributing to the degree of hazard: - Route of entry - Quantity of exposure - Physiological state - Environmental variables - Other factors
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Factors affecting toxicity


Chemical composition Physical state Routes of contacts Dose / concentrations Particle size Presence of other poisons Duration and frequency of exposure Tissue affinity and solubility in tissues Differential sensitivity of various tissues to certain chemicals Individual / genetic susceptibility

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Routes of contact
Respiratory tract;
Total alveoli surface area ; 50 100 m2 Size particle; > 30 microns; do not enter 5-30 microns; deposited in the nasopharynx 2-5 microns; tracheobronchiolar < 2 microns; reaches the alveoli epithelium

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Absorption through the skin


Skin is an excellent barrier Depends on;
Concentration of the toxic substance Duration of contact The thickness of the stratum corneum

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Absorption through the gastro intestinal tract depends on: Solubility of the material Active transport mechanisms Gastric motility Physical properties Co existent dietary deficiencies Injection Eye

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Dietary deficiency Calcium Iron

Enhanced toxicity Cadmium, Lead Cadmium, Lead, Manganese, Plutonium, Dimethylhydranine Cadmium, Lead, Mercury, Silver, Benzena, Ozone, PCBs Cd, Cu, Pb, Hg, Ethanol, Nitrosamines

Selenium

Zinc

Industrial toxicology 2007

Industrial toxicology 2007

Duration of exposures
Acute exposure ; minutes to few hours Sub acute; > few hours to 90 days Chronic; refers to prolonged and repeated exposure over 90 days Presence of other poisons produces additive, synergistic or reduction of adverse effect

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Classification of Chemical Hazards


Physical classes;
Gasses and vapours; Aerossols; Dust Fumes Mists Smoke

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Gas A substance in the gaseous state at room temperature and pressure. Gasses diffuse. Vapour. The gaseous form of the substance that is normally a liquid or solid at room temperature and pressure but which can be created by altering either these two factors. Vapours diffuse

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Aerosols a broad term referring to a solid or liquid particle dispersed in air.


Dust. Solid particles generated by handling, crushing, grinding etc of organic / inorganic materials. Fumes. Solid particles generated by the condensation from the gassier state generally after volatisation from molten metals and often accopmpanied by chemical reactions such as oxidation
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Mists- is a dispersion of liquid particles that may be in the visible range, while a fog is a visible of aerosol of liquids formed by condensation, e.g. oil mists produced during cutting and grinding operations Smoke. An aerosol resulted from incomplete combustion of carbon containing materials

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Material Safety Data Sheets


The information included: The identity of the substance Physical and chemical characteristics Potential physical hazards The health hazards including sign and symptoms

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The primary route(s) of entry Recommended exposure limits Whether the substance is listed on carcinogens report Any generally applicable precautions Emergency and first aid procedures

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The date of preparation of MSDS The name, address and telephone number of the manufacturer, importer, employer etc.

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Determining factors
The substance Composition physical state exposures etc. The person Genes, Age Other fact State of health Environ/ Allergy, habits climatic

poisoning
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Dose
Dose; amount of toxicant within cells of organs that manifests a toxicological effect Blood and urine concentrations;
usually reflect recent exposure correlate best acute exposure Exception example: Urinary cadmium ? Specification of toxicant in samples provide diagnostic insight. Methallothionein compound vs total toxicant
Industrial toxicology 2007

Industrial toxicology 2007

Industrial toxicology 2007

Industrial toxicology 2007

Industrial toxicology 2007

Non-linear dose-response curve with threshold

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Influencing host factors


Interaction depend on the metabolism pathways Protein complexes Susceptibility Life style Hypersensitivity reaction

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Personal factors
Genetic factors Age State of health Hipersensitivity or allergy Personal hygiene and other personal habits Pregnancy and lactation

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A measurement of the Hazard Evaluation (1) 1. Quantity available for absorption by the user, 2. Amount of time available for absorption, 3. Frequency the exposure occurs,

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A measurement of the Hazard Evaluation (2) 4. Physical form of the substances, 5. Toxicological properties and 6. Potency and the presence of other substances additives, or contaminants.

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1. Ventilation, Hazard Evaluation 2. appropriate hygienic practices, housekeeping, 3. protective clothing, and 4. proper training for safe handling .may eliminate or reduce hazards that may exist
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Prevention of exposure to toxic substances


Medical theory / examination Communication Substitution Segregation Enclosure Ventilation Personal hygiene Protective clothing Monitoring

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Management of poisoning cases


Removal from further exposure Detoxification Supportive therapy Replacement blood transfusion Organ transplantation

Industrial toxicology 2007

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