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Antigen:
recognized
as foreign binds to antigen-specific receptors on lymphocytes can be small or large can be any kind of biologic molecule
Immunogen:
can
induce or generate an immune response proteins and polysaccharides are good immunogens if they are large not all antigens are immunogens, some are small Thursday, January
23, 2014
Hapten:
antigenic,
i.e., binds antibody not immunogenic, cannot induce immune response frequently conjugated to carriers; haptencarrier complex is immunogenic and antibody against the HAPTEN will be generated free hapten will bind to antibody
Alergen
Bahan /material/antigen yang bisa menyebabkan terjadinya alergi Alergi: respon immune patologik , terjadi secara berlebihan sehingga merusak jaringan, diperantarai oleh Ig E . Sensitivitas thd Ag >>>> Terkait dengan reaksi hypersensitivitas type I
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Ag, Alergen
Hidrat arang (polisakarida) umumnya imunogenik Lipid non imunogenik + carrier imunogenik, ex Sfingolipid Asam Nukleat Non imunogenik +carrier imunogenik Protein imunogenik yang multideterminan univalen
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of antigen which binds antibody; usually an antigen is much larger than the antigen -combining region of antibody antibody binds only to a portion of the antigen can be recognized by B or T cell
Berdasar epitop
Unideterminan, univalen; hapten Unideterminan, multivalen; polisakarida Multideterminan, univalen; protein Multideterminan, multivalen; kimia kompleks
Terminology
Type I Hypersensitivity
Allergy Immediate type Local anaphylaxis Systemic anaphylaxis IgE mediated hypersensitivity Mast cells are involved the antigen is typically called an allergen
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1. Types of Anaphylaxis Generalized anaphylaxis Cutaneous anaphylaxis - localized 2. Cutaneous anaphylaxis- local reaction of antigen with homocytotropic antibody. Contributor to spontaneous disease: hypersensitivity reactions to insect bites, postvaccinal wheal and flare reactions
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Generalized anaphylaxis
a. Pathogenesis and Mediator Release Sensitization to antigen with IgE response IgE binds to mast cells and basophils Re-exposure causes degranulation of mast cells Mediators of immediate hypersensitivity disease
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Sensitization Phase Production Ig E Bind to FCe-R of Mast cell/basophil Activation Phase Re-exposure released granule of mast cell; Metilation Phospholipid membraneCa influx>> phospholipase GlikolisisEnergigranule movement cAMP<<cGMP>> degranulation Effector Phase Complex response from mediator of granule; histamin,bradikinin
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Chemokines
Eotaxin
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Sensitization Challenge Allergen (second binds to IgE exposure) on mast cells mediator release
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Clinical manifestation
Erythem ( red) vena delatation Edema release serum into tissue bronchoconstriction Peak 10-15 min after reexposure
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Type II Hypersensitivity
Cytotoxic antibody -- IgG or IgM reacts with antigen on cells and then complement activation destroys cells. (Also may have NK cell via ADCC cells involved) Hemolytic disease of the newborn (erythroblastosis fetalis) Transfusion reactions Anti-streptococcal M-protein crossreacts with heart muscle in rheumatic fever malaria infected RBCs coated with malaria antigens
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Anemia hemolitik autoimun; fagositosis eritrosithemolisis,anemia Trombositopenia purpura autoimun;fagositosisTrombositperdarahan Vaskulitis;degranulasi netrofil & inflamasi Goodpasture;inflamasi oleh komplemen &R-Fc nefritis Demam reumaaktifasi makrofage,inflamasimiokarditis Miastenia gravis: ikatan asetilkolin dihambatparalisis Diabetes insulin resisten; Ab mencegah ikatan insulinhiperglikemia Anemia pernisiosa; netralisasi faktor intrinsikenemia
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2. Mechanisms:
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Antigen-Antibody complexes form in antigen excess and are deposited in vessel walls, joints and glomeruli. Fixation of complement and neutrophil infiltration induces tissue damage and vasculitis, arthritis and glomerulonephritis. Antigen, Antibody and complement can be demonstrated in lesions
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Lymphocytic choriomeningitis Equine infectious anemia Chronic hog cholera Aleutian mink disease Feline leukemia virus infection
Thursday, January 23, 2014
Parasitic Diseases: Dirofilariasis Autoimmune diseases: Systemic lupus erythematosus Idiopathic (largest group of cases)
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SLE
antibodies
against DNA Women, primarily affected collection of syndromes, fever, joint paint, CNS damage, kidney type III hypersensitivity-leading to glomerulonephritis
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Hypersensitivity reactions
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Tugas
Kel Putra & Kel Putri; Manifestasi Oral alergi Presentasi besuk sabtu oleh wakil dari masing2x kelompok kelompok Pa : mas muchtar Pi : mbak leli
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