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History of HIV
• Originated in Africa in the late 1950’s
Prevalence of HIV
• Pandemic proportions
Prevalence of HIV
S.1 Origin and prevalence of HIV
Prevalence of HIV
S.2 Phases of HIV infection
• Category B:
– One or more related to an impaired immune system
– CD4 count between 200-499 cells/mm3
• Category C:
– At this point the person has AIDS in which they have one or
more of the AIDS opportunistic infections that eventually is the
cause of death
– CD4 count has fallen below 200 cells/mm3
S.2 Phases of HIV infection
Structure of HIV
• Two single strands of
RNA
• Enveloped with
spikes (Gp120)
• Carries 3 enzymes
– Reverse transcriptase
– Integrase
– Protease
S.3 HIV structure and life cycle
• Treatments:
– Drug therapy: highly active antiretroviral therapy (HAART)
used a combination of drugs to inhibit HIV replication
– Vaccines: as of 2006, 27 vaccines are being tested in
humans but results are not expected until 2010 but these will
not be a cure
S.3 HIV structure and life cycle
• In the US:
– 3% of people living with HIV live in the US
– For men:
• Male-male sexual contact is the main mode of transmission in the US (65%)
while heterosexual contact accounts for ~16%
– For women:
• Heterosexual contact accounts for 78% of HIV transmission
– African Americans are the hardest hit ethnic group
– About 1 million people living with HIV today and 25% do not know it