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    Surya Budikusuma
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    This document summarizes the process of leukopoiesis, or the formation and maturation of white blood cells. It discusses the major types of white blood cells produced, including granulocytes, lymphocytes, and monocytes. The bone marrow is identified as the main site of leukopoiesis, where hematopoietic stem cells differentiate into these white blood cell lineages through regulated stages of mitosis and maturation guided by hematopoietic growth factors. The process involves both myeloid and lymphoid pathways to produce the different white blood cell types.

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    lecture 8

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    (03) LEUKOPOIESIS

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    This document summarizes the process of leukopoiesis, or the formation and maturation of white blood cells. It discusses the major types of white blood cells produced, including granulocytes, lymphocytes, and monocytes. The bone marrow is identified as the main site of leukopoiesis, where hematopoietic stem cells differentiate into these white blood cell lineages through regulated stages of mitosis and maturation guided by hematopoietic growth factors. The process involves both myeloid and lymphoid pathways to produce the different white blood cell types.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
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    2K views30 pages

    Leukopoiesis

    Uploaded by

    Surya Budikusuma
    This document summarizes the process of leukopoiesis, or the formation and maturation of white blood cells. It discusses the major types of white blood cells produced, including granulocytes, lymphocytes, and monocytes. The bone marrow is identified as the main site of leukopoiesis, where hematopoietic stem cells differentiate into these white blood cell lineages through regulated stages of mitosis and maturation guided by hematopoietic growth factors. The process involves both myeloid and lymphoid pathways to produce the different white blood cell types.

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    of 30

    LEUKOPOIESIS

    I WAYAN SUGIRITAMA http://sugiritama.blogspot.com sugiritama@gmail.com

    LEUKOPOIESIS
    Formation and maturation of white blood cells Granulocytopoiesis Agranulocytopoiesis Monocytopoiesis Lymphoctye maturation

    Mature White Blood Cells

    NEUTROPHILS

    EOSINOPHILS

    BASOPHILS

    LYMPHOCYTES

    MONOCYTES

    BONE MARROW : The Site of Leucopoiesis


    Vascular compartment Extensive network of sinusoids . Hemopoietic compartment Islands of hematopoietic cells (Hemopoietic cells in various stage of maturation )

    HEMOPOIETIC GROWTH FACTORS


    Table 10-6 Gartner colour text histology page 242

    Regulated the hemopoiesis Produce by spesific cells Acts on spesific stem cells, progenitor cells, and
    precursor cells The route to deliver growth factor : Via blood stream Secrete near the hemopoietic cells Direct cell-cell contact Induced rapid mitosis or and differentiation Most ot them are glycoproteins

    GRANULOCYTOPOIESIS

    GRANULOCYTOPOIESIS
    Formation of the granulocytes (neuthrophil, eosinophil, and basophil) All of Granulocyte progenitor cell derive from CFC-S Granulocyte Progenitor :
    CFU-Eo : eosinophil lineage CFU-Ba : Basophil lineage CFU-GM
    CFU-G : Neutrophil line CFU-M : monocyte line

    Maturation of Granulocyte
    Granulocyte maturation divide into six stages Structural Changes :

    A decreased in cell size Condensation of nuclear chromatin Changes in nuclear shape An accumulation of cytoplasmic granule

    Maturation of Granulocyte
    (Table 10-8 Gartner colour text histology page 242)

    GRANULOCYTOPOIESIS
    Mature granulocyte leave the bone marrow then enter the circulation connective tissue

    Monocytopoiesis

    MONOBLAST
    Large cell (15-25 ) Nucleus oval Cytoplasm without granule or few azurophlic granule Differentiate to the Promonocyte

    PROMONOCYTE
    16-18 m in diameter Kidney shape nucleus Cytoplasm contain azurophilic granule Divide twice in the course of their development into monocytes

    MONOCYTE ON BONE MARROW


    Mature monocytes enter the bloodstream circulate. Monocyte enter the connective tissues, where they mature into macrophages.

    LYMPHOPOIESIS

    LYMPHOPOIESIS
    CFU-Ly divides form the CFU-LyB and CFU-LyT CFU-LyB migrate to bursa-equivalent location, divided B lymphocytes CFU-LyT undergo mitosis migrate to the Thymus T lymphocytes

    LYMPHOBLAST

    LYMPHOCYTE ON BONE MARROW

    LYMPHOCYTE

    CONCLUSION
    Leucocytosis is formation of WBC, occurs in Bone Marrow Granulocyte and monocyte derive from Myeloid stem cells, whereas limfocyte from Lymphoid Stem cell Leucocytosis involved the series of mitosis and differentiation Leucocytosis are regulated by several growth factor and Interleukin

    THANK YOU FOR YOUR ATTENTION

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