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Oxide Nano
Particles
Synthesis And Biological
N.H.K.S.Senathilake
Student Index 8558
Use Department of Chemistry
University of Colombo
Sri lanka, August 2009
What is nano technology.?
“ The Design, Fabrication and Utilization Of
materials,
Structures,
devices and systems
through control matter on the nanometer
scale and exploitation of novel
phenomena and properties (physical,
chemical, biological) at that length scale In
At Least One Dimension ”.
Nano particles to Nano structures
First generation Nano particles
E.g.-Fe2O3, Au, Ag, polystyrene particles
Advanced generation –
Further modification to
functionalize particles
Why ferities?-The unique feature of magnetic
Nano particles
Iron oxides having magnetic properties
with low relaxation time and less Fe2O3 or Fe3O4
toxic to biological systems Particles-1st generation
Biologically
active
Functionalize the particle surface or
magnetic
enclose them in a functioning Nano
nanoparticle to achieve biological, Particles-
medical benefit advanced
generation
Biological applications of MIONPs
Signal enhancers in MRI imaging
Uniform in size
Monodisperse
Smaller size
Synthesis protocols involves two common steps
short nucleation step,
slower growth process on the existing nuclei.
1. Micro emulsion
Controlling the very low interfacial tension in precipitation matrix
through the addition of a co surfactant (e.g., an alcohol of
intermediate chain length),
2.Co precipitation
Metal oxide precipitation and a polymerization reaction is carried out
at the same time so that the developing particles are trapped inside
the tiny polymer beads.
Synthesis of MNPs for biological use..ctd