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Introduction & history Epidemiology Pathophysiology Signs, symptoms and stages of RSD Complications, is it a systemic disease?, RSD spread Diagnosis Investigations Management Take home points
Introduction
Case 1 - A 20 year old female with history of right sided radiculopathy secondary to PID around a year back presented with history of pain and swelling right ankle - Subsequent course, pain in right shoulder and elbow - Injection pamidronate - Right temporomandibular joint pain and tinnitus Case 2 - Middle age adult male with history of minor shoulder trauma complaining of pain and dystonica episodes involving right shoulder.
History
RSD remains one of the most misunderstood, underdiagnosed and overdiagnosed conditions
WHATS IN A NAME?
Algodystrophy Major causalgia Mimo causalgia Reflex neurovascular dystrophy Morbus Sudeck Sudecks atrophy Minor causalgia
Neurovascular dystrophy
4. Dr Veldman
5. Dr Ralph Baron
Epidemiology
Common in younger adults - Mean age 41.8 years - Mean age of injury 37.7 years Females > males 2-3:1 Usually involves a single limb in early stage Duration from injury to onset can vary usually days to months Genetics Children
Pathophysiology
What is sympathetic system? What is its role in normal physiology? Sympathetically maintained pain (SMP) is not equal to RSD, pain is later sympathetically independent pain (SIP) SMP eg. chronic neuropathic pains Watershed zones- why peripheries are involved more? Mild trauma No RSD a misconception Why RSD can be aggravated by ice, inactivity and use of assisted devices?
Autonomic dysfunction
Pathological sympatho-afferent coupling: Peripheral nociceptors develop adrenergic sensitivity (mainly alpha-2 receptors) such that tonic sympathetic efferent activity leads to their activation Painful impulses via these nociceptors maintain the central nervous system in a sensitized state Painful and non-painful stimuli to the affected limb result in hyperalgesia and allodynia, respectively Catecholamine levels, however, are actually lower in the affected extremity, thus, it is not a problem of excessive sympathetic nerve output
3. Inflammation It may be in the form of swelling (edema), skin rash (neurodermatitis), inflammatory changes of the skin color (mottled or purplish, bluish or reddish or pale discolorations), tendency for bleeding in the skin, skin becoming easily bruised, inflammation and swelling around the joints as well as in the joints (such as wrists, shoulders, knee, etc.) which can be identified on MRI in later stages, and secondary freezing of the joints. 4. Insomnia and emotional disturbance Sympathetic sensory nerve fibers terminate in"limbic system".
CRPS types
Type 1 occurs after an illness or injury that did not directly damage a nerve in the affected area Type 2 follows a distinct nerve injury
Stages of CRPS
Stage I (acute 3months): A sympathetic dysfunction with thermatomal distribution of the pain. Redness and warmth. In stage one, the pain is usually SMP in nature. Dependent edema and hyperhydrosis.
Stage II (subacute 3-12months): The dysfunction changes to dystrophy manifested by edema (more constant), neurovascular instability with fluctuation of livedo reticularis and cyanosis causing change of temperature and color of the skin in matter of minutes.
Stage III (atrophic->12 months): The dystrophic changes include bouts of hair loss, ridging, dystrophic, brittle and discolored nails, skin rash, subcutaneous bleeding, neurodermatitis, and ulcerative lesions. Stage IV: Identifies the final stage of RSD / CRPS manifested by: Failure of the immune system, reduction of helper T-cell lymphocytes and elevation of killer T-cell lymphocytes. Orthostatic complaints. Intractable generalized extremity and visceral edema involving the abdomen, pelvis, lungs, and extremities .The same organs may eventually be subject to multiple abscesses due to failure of immune function. Ulcerative skin lesions. High risks of cancer and suicide.
Spread of RSD
Patterns of spread - Contiguous - Independent spread - Mirror image spread Whole body RSD
Diagnosis & Investigations (Diagnosis is clinical, No single test confirmatory, Investigations at best supportive)
Thermography
QSART (quantitative sudomotor axon reflex test) MRI NCV / EMG Dexa scan
Management
- A multidisciplinary approach utilizing pharmacotherapy, physical therapy and psychological therapy is most appropriate - No one doctor can treat RSD completely - Treat aggressively - No patient is alike - Do no harm
Individualize!
No protocol works for all patients with CRPS. It is dependent on current pain level, symptoms, and tolerance
Diet
Pharmacological
Topical- DMSO (dimethylsulfoxide), topical steroids, epsom (magnesium) salt dressings Oral corticosteroids Calcitonin Antidepressants (SSRI) Anticonvulsants Opiods Bisphosphonates Mannitol
Clonidine and yohimibine Baclofen, botulinum, clonazepam Ketamine (most recent development)
Interventional
Sympathetic blocks Epidural blocks (infusion pumps) Intrathecal baclofen Sympathectomy (surgical and chemical) Spinal cord stimulators Disadvantages
Avoid
Surgery or procedures during active CRPS Alcohol Excessive assistive devices, ice or immobilization
Thank you