Professional Documents
Culture Documents
Radiation Physics
IAEA Training Material on Radiation Protection in Nuclear Medicine
Nuclear Medicine Part 2: Radiation Physics 2
Objective
To become familiar with the basic knowledge in
radiation physics, dosimetric quantities and units to
perform related calculations, different types of
radiation detectors and their characteristics, their
operating principles, and limitations.
Nuclear Medicine Part 2: Radiation Physics 3
Content
Atomic structure
Radioactive decay
Production of radionuclides
Interaction of ionizing radiation with matter
Radiation quantities and units
Radiation detectors
Note: Radiation units & quantities are in the process of
undergoing consensus through ICRU and IAEA. There may
be changes necessitating incorporation in this CD.
Part 2. Radiation Physics
Module 2.1. Atomic structure
IAEA Training Material on Radiation Protection in Nuclear Medicine
Nuclear Medicine Part 2: Radiation Physics 5
THE ATOM
The nucleus structure
protons and neutrons = nucleons
Z protons with a positive electric charge
(1.6 10
-19
C)
neutrons with no charge (neutral)
number of nucleons = mass number A
The extranucleus structure
Z electrons (light particles with electric charge)
equal to proton charge but negative
Particle Symbol Mass Energy Charge
(kg) (MeV)
----------------------------------------------------------
Proton p 1.672*10
-27
938.2 +
Neutron n 1.675*10
-27
939.2 0
Electron e 0.911*10
-30
0.511 -
Nuclear Medicine Part 2: Radiation Physics 6
Identification of an Isotope
Nuclear Medicine Part 2: Radiation Physics 7
Ernest Rutherford (1871-1937)
Nuclear Medicine Part 2: Radiation Physics 8
Electron Binding Energy
Electrons can have only discrete energy levels
To remove an electron from its shell
E > electron binding energy
Discrete shells around the nucleus : K, L, M,
K shell has maximum energy (i.e. stability)
Binding energy decreasing when Z increases
Maximum number of electrons in each shell : 2 in K,
8 in L shell,
Nuclear Medicine Part 2: Radiation Physics 9
Ionization-Excitation
Energy
Nuclear Medicine Part 2: Radiation Physics 10
characteristic
radiation
Auger-
electron
De-excitation
Nuclear Medicine Part 2: Radiation Physics 11
The Nucleus
Energy Levels
The nucleons can occupy different energy levels and the nucleus can be present in a
ground state or in an excited state. An excited state can be reached by adding energy to
the nucleus. At deexcitation the nucleus will emit the excess of energy by particle
emission or by electromagnetic radiation. In this case the electromagnetic radiation is
called a gamma ray. The energy of the gamma ray will be the difference in energies
between the different energy levels in the nucleus.
Occupied levels
~8 MeV
0 MeV
ENERGY
Particle emission
Gamma ray
Deexcitation Excitation
Nuclear Medicine Part 2: Radiation Physics 12
Isomeric Transition
Normally the excited nucleus will undergo de-excitation within
picoseconds. In some cases, however, a mean residence time for
the excited level can be measured. The de-excitation of such a
level is then called isomeric transition (IT). This property of a
nucleus is noted in the label of a nuclide by adding the letter m in
the following way: technetium-99m, Tc-99m or
99m
Tc
Nuclear Medicine Part 2: Radiation Physics 13
Energy
particles
photons
Nuclear Excitation
Nuclear Medicine Part 2: Radiation Physics 14
alpha-particle
beta-particle
Gamma radiation
Nuclear De-excitation
Nuclear Medicine Part 2: Radiation Physics 15
Internal Conversion
characteristic
radiation
conversion
electron
Nuclear Medicine Part 2: Radiation Physics 16
Gamma Ray Spectrum
(characteristic of the nucleus)
Nuclear Medicine Part 2: Radiation Physics 17
IR: infrared, UV: ultraviolet
Photons are part of the
electromagnetic spectrum
Part 2. Radiation Physics
Module 2.2. Radioactive decay
IAEA Training Material on Radiation Protection in Nuclear Medicine
Nuclear Medicine Part 2: Radiation Physics 19
Stable Nuclides
long ranged
electrostatic
forces
short ranged
nuclear forces
p
p
n
Line of stability
Nuclear Medicine Part 2: Radiation Physics 20
Stable and Unstable Nuclides
Too many
neutrons
for stability
Too many
protons
for stability
Nuclear Medicine Part 2: Radiation Physics 21
Radioactive Decay
Fission
The nucleus is divided into two parts, fission fragments. and
3-4 neutrons. Examples: Cf-252 (spontaneous), U-235 (induced)
o-decay
The nucleus emits an o-particle (He-4). Examples: Ra-226, Rn-222
|-decay
Too many neutrons results in |
-decay. n=>p
+
+e
-
+v. Example:H-3,
C-14, I-131.
Too many protons results in |
+
-decay
p
+
=>n+ e
+
+v
Examples: O-16, F-18
or electron capture (EC).
p
+
+ e
-
=>n+v
Examples: I-125, Tl-201
86
226
84
222
2
4
Ra Rn+ o
Nuclear Medicine Part 2: Radiation Physics 22
It is impossible to know at what time a certain radioactive nucleus
will decay. It is, however possible to determine the probability l
of decay in a certain time. In a sample of N nuclei the number of
decays per unit time is then:
2 ln
T
e N = N(t)
N
dt
dN
2 / 1
t -
0
=
Radioactive Decay
Nuclear Medicine Part 2: Radiation Physics 23
The number of decaying nuclei per unit of time
1 Bq (becquerel)=1 per second
Activity
Nuclear Medicine Part 2: Radiation Physics 24
1 Bq is a small quantity
3000 Bq in the body from natural
sources
20 000 000-1000 000 000 Bq in nuclear
medicine examinations
Nuclear Medicine Part 2: Radiation Physics 25
Multiple & Prefixes (Activity)
Multiple Prefix Abbreviation
1 - Bq
1 000 000 Mega (M) MBq
1 000 000 000 Giga (G) GBq
1 000 000 000 000 Tera (T) TBq
Nuclear Medicine Part 2: Radiation Physics 26
Henri Becquerel 1852-1908
Nuclear Medicine Part 2: Radiation Physics 27
Maria Curie 1867-1934
Nuclear Medicine Part 2: Radiation Physics 28
Parent-Daughter Decay
A C B
2
) e e (
A
B(t)
e A = A(t)
t t
1 2
2 0
t 1 -
0
2 1
-
292 keV
T = 2*10
5
y
99
Ru stable
12.4%
-
442 keV
739 keV
T = 2.75 d
Nuclear Medicine Part 2: Radiation Physics 31
Irene Curie (1897-1956)
&
Frederic Joliot (1900-1958)
Part 2. Radiation Physics
Module 2.4. Interaction of Ionizing
Radiation with Matter
IAEA Training Material on Radiation Protection in Nuclear Medicine
Nuclear Medicine Part 2: Radiation Physics 33
Ionizing Radiation
Charged particles
alpha-particles
beta-particles
protons
Uncharged particles
photons (gamma- and X rays)
neutrons
Each single particle can cause ionization,
directly or indirectly
Nuclear Medicine Part 2: Radiation Physics 34
Charged Particles Interaction
with Matter
heavy
light
Macroscopic Microscopic
Nuclear Medicine Part 2: Radiation Physics 35
Beta particles Alpha particles
Transmission
Charged Particles
Nuclear Medicine Part 2: Radiation Physics 36
Mean Range of |-particles
0,01
0,1
1
10
0,16 1 5 10 50 100 500 1000 5000
Mean range (mg/cm2)
E
n
e
r
g
y
(
M
e
V
)
Radionuclide Max energy Range (cm) in
(keV) air water aluminium
-------------------------------------------------------------------------------------
H-3 18.6 4.6 0.0005 0.00022
C-14 156 22.4 0.029 0.011
P-32 1700 610 0.79 0.29
Nuclear Medicine Part 2: Radiation Physics 37
Bremsstrahlung
Photon
Electron
Nuclear Medicine Part 2: Radiation Physics 38
Bremsstrahlung Production
The higher the atomic number of the X-
ray target, the higher the yield
The higher the incident electron energy,
the higher the probability of X-ray
production
At any electron energy, the probability
of generating X-rays decreases with
increasing X-ray energy
Nuclear Medicine Part 2: Radiation Physics 39
X-ray Production
High energy electrons hit a (metallic)
target where part of their energy is
converted into radiation
target
electrons
X-rays
Low to
medium
energy
(10-400keV)
High
> 1MeV
energy
Nuclear Medicine Part 2: Radiation Physics 40
X-Ray Tube for low and
medium X-ray production
Nuclear Medicine Part 2: Radiation Physics 41
Megavoltage X-ray Linac
target
electrons
X-rays
Nuclear Medicine Part 2: Radiation Physics 42
Issues with X-ray Production
Angular distribution: high energy X-rays are
mainly forward directed, while low energy X-
rays are primarily emitted perpendicular to
the incident electron beam
Efficiency of production: In general, the
higher the energy, the more efficient is X-ray
production - this means that at low energies
most of the energy of the electron (>98%) is
converted into heat - target cooling is
essential
Nuclear Medicine Part 2: Radiation Physics 43
The Resulting X-Ray Spectrum
Unfiltered radiation (in vacuum)
20 40 60 80 100 120
INTENSITY
PHOTON ENERGY (keV)
Characteristic
X-rays
Bremsstrahlung
Spectrum after
filtration
Maximum electron energy
Nuclear Medicine Part 2: Radiation Physics 44
absorption
scattering
transmission
energy deposition
Photons Interaction with Matter
Nuclear Medicine Part 2: Radiation Physics 45
photon
characteristic
radiation
electron
Photoelectric Effect
Nuclear Medicine Part 2: Radiation Physics 46
photon
electron
scattered
photon
Compton Process
Nuclear Medicine Part 2: Radiation Physics 47
Pair Production
photon
positron
electron
Nuclear Medicine Part 2: Radiation Physics 48
Annihilation
|
+
+ e
-
(511 keV) (511 keV)
|
+ (1-3 mm)
Radionuclide
Nuclear Medicine Part 2: Radiation Physics 49
Photon Interaction
0
10
20
30
40
50
60
70
80
90
100
0,01 0,1 1 10 100
Photon energy (MeV)
Photoelectric
effect
Compton
process
Pair
production
The dominating photon absorption process in different materials of different atomic numbers
Photon energy (MeV)
Atomic number (Z)
Nuclear Medicine Part 2: Radiation Physics 50
N N e
d
=
0
d: absorber thickness
: attenuation coefficient
HVL: half value layer TVL: tenth value layer
Transmission-Photons
Nuclear Medicine Part 2: Radiation Physics 51
HVL
Thickness of an absorber necessary to reduce the transmission of radiation to 50 percent
(HVL).
Radiation quality HVL (mm)
Concrete Lead
50 kV
100 kV
200 kV
500 kV
1 MV
2 MV
5 MV
10 MV
20 MV
4. 3
10. 6
25
36
44
64
96
119
137
0. 06
0. 27
0. 52
3. 6
7. 9
12. 5
16. 5
16. 6
16. 3
Part 2. Radiation Physics
Module 2.5. Radiation Quantities and
Units
IAEA Training Material on Radiation Protection in Nuclear Medicine
Nuclear Medicine Part 2: Radiation Physics 53
High absorbed energy per unit mass
Many ionizations per unit mass
Increased risk of biological damage
Energy Absorption
Nuclear Medicine Part 2: Radiation Physics 54
Absorbed Dose
Absorbed energy per mass unit
1 Gy (gray)=1 J/kg
Nuclear Medicine Part 2: Radiation Physics 55
Harold Gray 1905-1965
Nuclear Medicine Part 2: Radiation Physics 56
1 Gy is a relatively large Quantity
Radiotherapy doses > 1Gy
Dose from nuclear medicine
examination typically 0.05-0.001Gy
Annual background radiation due to
natural radiation (terrestic, cosmic, due
to internal radioactivity, Radon,) about
0.002-0.004 Gy
Nuclear Medicine Part 2: Radiation Physics 57
Fractions & Prefixes (Dose)
Fraction Prefix Abbreviation
1 - Sv
1/1000 milli (m) mSv
1/1,000,000 micro () Sv
Nuclear Medicine Part 2: Radiation Physics 58
A note of caution:
Energy deposition in
matter is a random
event and the
definition of dose
breaks down for
small volumes (e.g.
a single cell). The
discipline of Micro-
dosimetry aims to
address this issue.
Adapted from Zaider 2000
Nuclear Medicine Part 2: Radiation Physics 59
H
e
= w
r
* D
D: absorbed dose (Gy), w
r
: radiation weighting factor (1-20)
H
eff
=w
T
*H
e
H
e
: equivalent dose (Sv), w
T
: tissue weighting factor (0.05-0.20)
Unit: 1 Sv (sievert)
Equivalent Dose/
Effective Dose
Nuclear Medicine Part 2: Radiation Physics 60
Effective Dose
E w H
T
T
T
=