FROM (PHOSPHO)LIPID SELF-ASSEMBLIES TO

NANOSTRUCTURES – COLLOID AND SURFACE SCIENCE

REVISITED

Erhan Süleymanoğlu

Bilkent University,
Faculty of Science,
Department of Chemistry
Ankara
April-2002
Nanotechnology
The Scope of Nanoscience
Nanomaterials
Prerequisites
Rational Design and Engineering of Delivery Systems for Therapeutics: Biomedical
Implications from Colloid and Surface Science
 Therapeutic Applications
Nanoscale aggregates

Liposome Nanoemulsion Lipid Solid

nanoparticle nanoparticle

Inorganic - inorganic core shell Inorganic - organic core shell Organic - organic core shell

Quantum particle Magnetic particle Drug carrier particle

Fluorescent Drug carrier particle

PS-g-PAA micelles
stained with
Pb(Ac)3
G. Carrot, J. C. Valmalette, C.
J. G. Plummer, S. M. Scholz, J.
Dutta, H. Hofmann and H.
Hilborn; Colloid and Polymer
Science 276 (1998) 853-859 TEM image of a negatively stained
DNA linked Au particles, C.A. Mirkin nanocapsule (A. Fery, MPI-Golm)
BIOMAT 190802MH
 Polyelectrolyte Approaches
• Micelles
 Polyelectrolyte Approaches
• Surfactants
 Polyelectrolyte Approaches
• Synthetic Polycations
 Polyelectrolyte Approaches
• Synthetic Polycations
Dendrimers
Size Distributions of Various
Cationic Polymer Based
Nanostructures
 Polyelectrolite Approaches
• Cationic Lipids
Cell Membrane
The major hurdles for cellular internalization
Phospholipids
Polar Head Groups

Three carbon glycerol
 What is a liposome?

– Spherical vesicles with a phospholipid bilayer

Hydrophilic

Hydrophobic
(2) Classification of Liposome Based
on size

SUV: Small unilamellar vesicles,

LUV: Large unilamellar vesicles,
MLV: Multilamellar vesicles,
MVV: Multivesicular vesicles
Liposomal Formulations
 (A) (B) (C)

Liposomes
• (A) A aqueous soluble drug encapsulated in aqueous compartment
• (B) A hydrophobic drug in the liposome bilayer
• (C) A hydrophilic polyoxyethylene lipids incorporated into
liposome
 Classification of Liposomes
(1) Classification of Liposome Based on Function
● Conventional

● Stealth: 표면에 고분자로 특수 코팅

을 하고 크기를 조절 함으로서 대식세포에
의해 소멸되는 것을 막으며 이에 따라 혈
중 내 작용시간과 효과를 최대화 시킨 것 .

● Targeted: 표면에 Target 을 향하

게 하는 ligand 를 붙인것

● Cationic: 음이온성 물질 , 특히
DNA 를 수송하는데 사용된다 .
Classes of Liposomes
Conventional Long circulating

Immuno Cationic
Methods of Preparation