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Dermatophytes
Dermatophytes (name based on the Greek for 'skin plants') are a common label for a group of three types of fungus that commonly causes skin disease in animals and humans. These anamorphic (asexual or imperfect fungi) genera are: Microsporum, Epidermophyton and Trichophyton. There are about 40 species in these three genera.
Terbinafine hydrochloride
FDA approval
On September 28, 2007, the FDA stated that terbinafine hydrochloride is a new treatment approved for use by children age 4 and up.
The antifungal can be used to treat ringworm of the scalp, Tinea capitis.
Pharmacokinetics
Following oral administration, Terbinafine is well absorbed (>70%) and the bioavailability of Terbinafine tablets as a result of first-pass metabolism is approximately 40%. Peak plasma concentrations appear within 2 hours after a single 250 mg dose; the AUC (area under the curve) is approximately 4.56 g.h/mL. An increase in the AUC of Terbinafine of less than 20% is observed when Terbinafine tablets are administered with food.
Pharmacokinetics
In plasma, Terbinafine is >99% bound to plasma proteins and there are no specific binding sites. Terbinafine is distributed to the sebum and skin. The increase in plasma AUC is consistent with an effective half-life of ~36 hours. A terminal half-life of 200-400 hours may represent the slow elimination of Terbinafine from tissues such as skin and adipose.
Mechanism of action
Terbinafine, an antifungal, inhibits biosynthesis of ergosterol, an essential component of fungal cell membrane, via inhibition of squalene epoxidase enzyme.
This results in fungal cell death primarily due to the increased membrane permeability mediated by the accumulation of high concentrations of squalene but not due to ergosterol deficiency.
Mechanism of action
Depending on the concentration of the drug and the fungal species, Test in vitro, Terbinafine may be fungicidal.
Mechanism of action
huma fungus
Depending on the concentration of the nucleic acid synthesis nucleic acid synthesis drug and the fungal species, Test in vitro, protein synthesis protein Terbinafine may be fungicidal. synthesis
cholesterol ergosterol chitin synthesis glucan synthesis mannan synthesis
Onychomycosis
Onychomycosis is defined as the fungal infection of the nail. It is the most common disease of the nails and can constitute to about a half of all nail abnormalities. Onychomycosis can affect either the toenails or the fingernails. However, it is particularly common in toenails. Approximately 6-8% of the adult population has onychomycosis.
Onychomycosis
Onychomycosis is defined as the fungal infection of the nail. It is the most common disease of the nails and can constitute to about a half of all nail abnormalities. Onychomycosis can affect either the toenails or the fingernails. However, it is particularly common in toenails. Approximately 6-8% of the adult population has onychomycosis.
Adverse Effect:
Common: Headache, feeling of fullness, loss of appetite, indigestion, feeling sick, mild stomach pain, diarrhoea Uncommon: Taste disturbances and loss of taste sense. Rare : Pins and needles or tingling, reduced sense of touch, dizziness, a feeling of general discomfort and illness, tiredness, joint pain (arthralgia), muscle pain (myalgia). Skin Reactions: If progressive skin rash occurs, treatment should be discontinued.
CLINICAL PHARMACOLOGY
Pharmacokinetics This is a locally acting locally applied preparation with minimal systemic absorption (<5%). Therefore, systemic pharmacokinetics is not relevant. Pharmacodynamics The pharmacodynamic effects of terbinafine have been well established both as a topical agent and for systemic administration in the indications sought.
Additional informations
What are the symptoms and signs of athlete's foot? Most individuals with athlete's foot have no symptoms at all and do not even know they have an infection. Many may think they simply have dry skin on the soles of their feet. Common symptoms of athlete's foot typically include various degrees of itching and burning. The skin may frequently peel, and in particularly severe cases, there may be some cracking, pain, and bleeding as well. Rarely, athlete's foot can blister (called bullous tinea pedis).
Additional informations
Additional informations
Additional informations
Cutaneous cadidyasis
Jock itch
Ring worm
Additional informations
Pityriasis versicolor is a common skin complaint in which flaky discoloured patches appear mainly on the chest and back. It is sometimes called tinea versicolor, refer to infection with a dermatophyte fungus.
References