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  • Androgens in Rheumatoid Arthritis When Are They Effectors

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    Jaye Cobb Rosenstock
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    Neither hormone receptor genes nor plasma androgens seem significantly altered in female subjects before they became affected by rheumatoid arthritis (RA) serum testosterone levels are inversely correlated with RA activity. Male gender has been found to be a major predictor of remission in early RA.

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    Neither hormone receptor genes nor plasma androgens seem significantly altered in female subjects before they became affected by rheumatoid arthritis (RA) serum testosterone levels are inversely correlated with RA activity. Male gender has been found to be a major predictor of remission in early RA.

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    8 views2 pages

    Androgens in Rheumatoid Arthritis When Are They Effectors

    Uploaded by

    Jaye Cobb Rosenstock
    Neither hormone receptor genes nor plasma androgens seem significantly altered in female subjects before they became affected by rheumatoid arthritis (RA) serum testosterone levels are inversely correlated with RA activity. Male gender has been found to be a major predictor of remission in early RA.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
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    Androgens in rheumatoid arthritis: when are they effectors? - <a href="../public/authorSummary-...

    http://www.curehunter.com/public/pubmed19804618.do

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    Androgens in rheumatoid arthritis: when are they effectors?


    Abstract Neither hormone receptor genes nor plasma androgens seem significantly altered in female subjects before they became affected by rheumatoid arthritis (RA) and, therefore, do not seem to play a role as risk factors for its development. However, serum testosterone levels are inversely correlated with RA activity and dehydro-epiandrosterone sulfate (DHEAS) plasma levels are inversely correlated with both disease duration and clinical severity in patients already affected by active RA. In particular, gonadal and adrenal androgens (that is, testosterone and DHEAS) are significantly decreased in inflamed synovial tissue/fluids during active disease as a consequence of the inflammatory reaction, which supports a pro-inflammatory milieu in RA joints. Recently, male gender has been found to be a major predictor of remission in early RA. Maurizio Cutolo Arthritis research & therapy (Arthritis Res Ther) Vol. 11 Issue 5 Pg. 126 ( 2009) ISSN: 1478-6362 [Electronic] England 19804618 (Publication Type: Comment, Editorial, Review) Androgens Androgens (metabolism) Arthritis, Rheumatoid (metabolism, pathology, physiopathology) Female Humans Male
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    6/2/2010 3:48 PM

    Androgens in rheumatoid arthritis: when are they effectors? - <a href="../public/authorSummary-...

    http://www.curehunter.com/public/pubmed19804618.do

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    CureHunter Inc. provides medical information and specifically does NOT provide medical advice. We wish to acknowledge and thank the US National Library of Medicine and Medline staff for providing access to their data. Copyright 2003-2010 CureHunter Inc., MeSH copyright NLM, Journal Articles copyright original owners.

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