Resveratrol

Resveratrol

Resveratrolfreetrial.com/>Resveratrol The dosage associated with any nutraceutical or pharmaceutical is always an important consideration. Dosage contributes to both the efficacy and the potential-side effects. The best way, of course, to determine the dosage is through human clinical trials. In order to get a general idea of dosage, scientists first conduct trials on animals - typically mice, rats, primates, etc. For an 80 kg (176 lb) person, the 200-400 mg/kg of body weight amount used in Auwerx's mouse study. Another researcher at Harvard used 5-30 mg/kg. Subscribing to the 'allometric scaling' by body surface area method, you divide by 12 to go from mouse to human, yielding ~150 mg or ~2g [2,000 mg] as the respective human-equivalent doses. In human studies, the first thing to test for is potential toxicity. Human clinical trials have been shown to have few if any side effects at very high dosages, and no toxicity even at extremely high dosages 5g (5,000 mg). Naturally, the only way to truly determine the best human dosage is to give it to humans. In 2006, Xenomis, LLC.conducted a study on humans in conjunction with Dr. James Smoliga of Marywood University using the formulation: 400 mg of 98% pure Resveratrolfreetrial.com/>Resveratrol 400 mg Red Wine Grape extract 100 mg Quercetin The Smoliga study showed significant improvements in energy level, strength, endurance, and verbal memory. A second study is underway with 400 mg of Naturex Powergrape a red-wine grape extract. In a recent email exchange, Dr. Smoliga commented on Resveratrolfreetrial.com/>Resveratrol dosage as follows: 'There are one or two articles examining the pharmacokinetics of dosage (combined with safety) which found it to be safe in up to 5g (5,000 mg) doses. It appears that with dosages in the 400 mg range, it reaches a peak and then subsides, whereas in the 1g (1,000 mg) or more range, higher blood concentrations are maintained. However, I believe it is not yet certain whether which would be more advantageous - to have a rise in fall in Resveratrol concentration or a steady level of Resveratrol. Based on some of the physiology, I would think a rise and fall mechanism would actually be more beneficial, and if this is the case the 400mg dosage should work quite nicely.' Products made with high dosages of Resveratrolfreetrial.com/>Resveratrol (400-500 mg per capsule or tablet) generally cost more and use the highest quality 98% pure Resveratrolfreetrial.com/>Resveratrol (the purity should be on the Supplement Label). Such a high quantity and quality of Resveratrolfreetrial.com/>Resveratrol can cost as much as $600 - $800 per kg! As you would expect, these products are more expensive because the ingredients cost more. Some companies recommend a 800-1,000 mg dosage, but that many milligrams simply cannot fit into a single capsule or tablet. The best way to increase dosage is to take multiple pills. Whatever you buy, make sure to read the product Supplement Facts. It's the only way to be sure what you're getting. Please remember, if you can't find the dosage on the company's website or label, I sincerely recommend not buying that supplement. Here's an example Supplement Facts from Vindure 900. There have been many studies conducted in order to investigate the right dosage of Resveratrolfreetrial.com/>Resveratrol for humans. In the animal studies that were conducted, larger doses proved to be greater. In human clinical trials, high dosages have had few, if any, side effects, and no toxicity, even at the highest dosages (5,000 mg). One way to determine the best Resveratrolfreetrial.com/>Resveratrol dosage for humans is from animal studies. This is how pharmaceutical companies conduct their early trials. There are many factors including body mass (mg/pound), metabolism of the animal/human, etc. (In Auwerx's Mouse Study, for a person weighing 80 kg (176 lbs), the 400 mg/kg of body weight used in the study would come to 32,000 mg/day. Since humans have slower metabolic rates than mice, this would change the equivalent human dosage to roughly 4571 mg/day.) Naturally, the only way to truly determine the best human dosage is to give it to humans. In 2006, Xenomis, LLC.conducted a study on humans in conjunction with Dr. James Smoliga of Marywood University using the formulation: 400 mg of 98% pure Resveratrolfreetrial.com/>Resveratrol 400 mg Red Wine Grape extract 100 mg Quercetin Products made with high dosages of Resveratrolfreetrial.com/>Resveratrol (400-500 mg per capsule or tablet) generally cost more and use the highest quality 98% pure Resveratrolfreetrial.com/>Resveratrol (the purity should be on the Supplement Label). Such a high quantity and quality of Resveratrolfreetrial.com/>Resveratrol can cost as much as $600 - $800 per kg! As you would expect, these products are more expensive because the ingredients cost more. Some companies recommend a

Resveratrol

800-1,000 mg dosage, but that many milligrams simply cannot fit into a single capsule or tablet. The best way to increase dosage is to take multiple pills. Regardless of what brand or dosage you purchase, make sure to read the product Supplement Facts. Reading the Supplement Facts is the best way to know exactly what you're getting. If the facts aren't on the company's website, it probably isn't wise to buy their supplement. Here's an example of Supplement Facts from Vindure 900. In any pharmaceutical or nutraceutical concept, the dosage is an extremely important consideration. The dosage of a substance is responsible for both its efficacy and its potential side effects. Human clinical trials have always been the best way to determine the correct dosage. One way to determine the best Resveratrolfreetrial.com/>Resveratrol dosage for humans is from animal studies. This is how the same way the pharmaceutical companies conduct their early trials. There are many factors including body mass (mg/pound), metabolism of the animal/human, etc. (Auwerx's Mouse Study -For an 80 kg (176 lb) person, the 400 mg/kg of body weight amount used in Auwerx's mouse study would come to 32,000 mg/day. Compensating for the fact that humans have slower metabolic rates than mice would change the equivalent human dose to roughly 4571 mg/day.) Of course, the best way to determine human dosage is to give it to humans. In 2006, Xenomis, LLC.conducted a study on humans in conjunction with Dr. James Smoliga of Marywood University using the formulation: 400 mg of 98% pure Resveratrolfreetrial.com/>Resveratrol 400 mg Red Wine Grape extract 100 mg Quercetin The Smoliga study showed significant improvements in energy level, strength, endurance, and verbal memory. A second study is underway with 400 mg of Naturex Powergrape a red-wine grape extract. We recently posed this question of Resveratrolfreetrial.com/>Resveratrol Dosage to two (2) world-renowned Professors at Marywood University and the University of Pennsylvania who have been doing research on Resveratrolfreetrial.com/>Resveratrol for over 7 years. Their names are not contained in this article, as they do not wish to be seen as endorsing any products. Here are their email responses to me. Professorat Marywood University 'I believe there are one or two articles examining the pharmacokinetics of it (dosage) (combined with safety) which found it to be safe in up to 5g (5,000 mg) doses, I believe. It appears that with dosages in the 400 mg range, it reaches a peak and then subsides, whereas in the 1g (1,000 mg) or more range, higher blood concentrations are maintained. However, I believe it is not yet certain whether which would be more advantageous - to have a rise in fall in Resveratrol concentration or a steady level of Resveratrol. Based on some of the physiology, I would think a rise and fall mechanism would actuallly be more beneficial, and if this is the case the 400mg dosage should work quite nicely.' Professor at University of Pennsylvania 'I have attached the clinical trial mentioned by (the Professor at Marywood). Sirtris (Pharmaceuticals) also went up to 5g (5,000 mg) of their 'SRT501%u2033 formulation without any ill effects:' http://.com/clinical_trials/sirtris-announces-positive-results-proprietary-version-Resveratrol-srt501phase-1b-type-2-diabetes-3127.html 'We used ~5-30 mg/kg in our mice, and Johan Auwerx used 200400 mg/kg. If you subscribe to the 'allometric scaling' by body surface area method, you divide by 12 to go from mouse to human, yielding ~150 mg or ~2g (2,000 mg) as the respective human-equivalent doses. But since other polyphenols may have an additive or synergistic effect, I think it's quite likely that Vindure is delivering the effect of a 2g (2,000 mg) dose of pure Resveratrol - I would love to see pharmacokinetic data comparing Vindure to the Resveratrol alone.' Products in the high-range of Resveratrolfreetrial.com/>Resveratrol (400 - 500 mg per capsule or tablet) cost more, and generally use the highest quality 98% pure Resveratrolfreetrial.com/>Resveratrol (be sure the purity is on the Supplement Label). The cost of this high quantity and high quality Resveratrolfreetrial.com/>Resveratrol is $600 - $800 per kg! So naturally, these products carry a higher price, because the ingredients cost more. Some companies recommend a800 - 1,000 mg dosage, but no company includes that much Resveratrolfreetrial.com/>Resveratrol in a single capsule or tablet because they simply can't fit that many milligrams into a pill. Taking multiple pillsis the best way to increase dosage. Whatever you buy, make sure to read the product Supplement Facts.

Resveratrol