Taylor Choi

Des Plaines, IL 60016 (224) 374-3693 taylor.a.choi@gmail.com SUMMARY OF QUALIFICATIONS Over 5 years of experience in preclinical drug discovery from medicinal chemistry to in vivo biological profiling Over 4 years of experience working with mammalian cells and infectious agents in bio-safety laboratory 3 Extensive hands-on experience with functional assay techniques, including HPLC-MS/MS, NMR, chromatographies, and animal studies Experienced in developing and executing HPLC-MS/MS methods for quantification of compounds Executed experiments, analyzed data, and compiled findings into presentation-quality format to meet the collaborators deadlines

EXPERIENCE Post-Doctoral Fellow University of Medicine and Dentistry of New Jersey, Newark, NJ (11/2009 - 07/2010) Wrote, reviewed, revised and validated standard operating protocols Trained lab personnel on mammalian cell-based assays Conducted monthly inventory of Biological Select Agents and Toxins according to the CDC Select Agent Program Managed mammalian and bacterial cell lines Planned and executed projects to completion in timely manner Prepared samples and tested for the inhibitory activity against M. tuberculosis and various Biological Select Agents and Toxins in a Bio-safety Level 3 containment laboratory Analyzed experimental data, interpreted results and presented findings at weekly meetings Shared ideas and scientific strategies at weekly meetings in order to improve HTS Post-Doctoral Fellow Institute for Tuberculosis Research (UIC), Chicago, IL (05/2009 10/2009) Developed, validated, and executed HPLC-MS/MS methods to analysis of drug-like compounds Troubleshooted analytical methods and laboratory instrumentation Analyzed concentrations of compounds in plasma and lung tissues using HPLC-MS/MS

 Developed formulations to overcome the water-solubility and permeability challenges of compounds Collaborated with other colleagues to design bioavailability protocols Actively participated in meetings where potential challenges were identified and addressed as well as future projects and ideas were discussed Reviewed relevant scientific literature pertaining to assigned projects and applied pertinent information about the techniques to research Research Assistant Institute for Tuberculosis Research (UIC), Chicago, IL (10/2006 - 05/2009) Developed and validated standard operating protocols for drug metabolism and pharmacokinetics studies Developed formulations to overcome the water-solubility and permeability challenges of compounds Assessed pharmacokinetic parameters of prospective anti-TB compounds in mice using HPLC-MS/MS Evaluated protein binding, cytotoxicity, microsomal and chemical stabilities of anti-TB drug candidates Managed mammalian and bacterial cell culture lines Designed and synthesized new target molecules based on rational hypotheses Mentored a graduate student on experiments pertaining to drug metabolism and pharmacokinetics studies Research Assistant Technische Universitt Dresden, Germany (10/2005 - 09/2006) Synthesized carbazole derivatives Characterized synthesized compounds using 1H and 13C NMR, UV-VIS, GC-MS, FTIR Supervised 2 students per quarter in laboratory Research Intern Hollister, Libertyville, IL (03/2004 - 08/2004) Conducted stability testing on ostomy bags and cord clamps Executed package air test and package seal strength Performed quality control testing according to GMP guidelines

EDUCATION University of Illinois at Chicago, Chicago, IL (2009) Doctorate in Pharmacognosy University of Illinois at Chicago, Chicago, IL (2003) Bachelor of Science in Biochemistry, Cum Laude

SKILLS Laboratory: Small animal handling, blood collection, necropsy Dose formulations Assays including protein binding by equilibrium dialysis, microsomal stability, macrophage and cytotoxicity Mammalian and bacterial cell culture Polymerase chain reaction Instrumentation: HPLC-tandem MS (ABI QTRAP 3200, Shimadzu IT-TOF, Agilent QQQ) Analytical and preparatory HPLC NMR, flash-column chromatography, automated microwave synthesizer (CEM), TLC UV spectrometer, GC-MS, FTIR, IC PAMPA General/Software: Apple Works/PC Office WinNonLin, GraphPad Prism ChemOffice Endnote SPSS Derek, MetaSite

AWARDS Gordon Research Conference--Drug Metabolism Chairmans Fund (2008) Paul Sang Memorial Scholarship, UIC (2008)

PROFESSIONAL AFFILIATIONS The New York Academy of Sciences American Chemical Society American Society of Pharmacognosy

PRESENTATIONS Choi, Taylor A.; Klein, Larry, L.; Pak, Dennis; Wan, Baojie; Wang, Yuehong; Franzblau, Scott G. Gordon Research Conference: Tuberculosis Drug Development, Oxford,

United Kingdom, August 16-21, 2009. Choi, Taylor A.; Pak, Dennis; Wan, Baojie; Wang, Yuehong; Chen, Yufeng; Kozikowski, Alan P.; Franzblau, Scott G. Tetrahydro-beta carbolines as novel antituberculosis agents. Abstracts of Papers, 235th ACS National Meeting, New Orleans, LA, United States, April 6-10, 2008. Choi, Taylor A.; Czerwonka, Regina; Frhner, Wolfgang; Krahl, Micha P.; Reddy, Kethiri R.; Franzblau, Scott G.; Knlker, Hans-Joachim. Synthesis and antitubercular activities of carbazoles. 45th MIKI Meeting, University of Kansas, KS, United States, 2007.

PUBLICATIONS Cordell, Geoffrey A.; Choi, Taylor A. Alkaloids and their biosynthesis. Natural Products Encyclopedia of Life Support Systems (EOLSS), developed under the auspices of the UNESCO, Oxford, UK. Accepted. Choi, Taylor A.; Franzblau, Scott G. Tetrahydro--carbolines. (provisional patent) Technology identification number DB095. May 06, 2008. Choi, Taylor A; Czerwonka, Regina; Forke, Ronny; Jger, Anne; Knll, Jan; Krahl, Micha P.; Krause, Tilo; Reddy, Kethiri R.; Franzblau, Scott G.; Knlker, Hans-Joachim. Transition metals in organic synthesis Part 83: Synthesis and pharmacological potential of carbazoles. Med. Chem. Res. (2008), 17, 374. Choi, Taylor A.; Czerwonka, Regina; Frhner, Wolfgang; Krahl, Micha P.; Reddy, Kethiri R.; Franzblau, Scott G.; Knlker, Hans-Joachim. Synthesis and activity of carbazole derivatives against Mycobacterium tuberculosis. ChemMedChem (2006), 1(8), 812.