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TOXICOLOGY
The harmful effects of chemicals on
biological systems
DEFINITIONS
TOXICITY - the capacity of a chemical agent to
cause harm when absorbed into the body.
HAZARD - the toxicity, and the probability that the
chemical agent will be absorbed and cause harm
under a specified set of conditions.
60
50
Response
40
30
20
10
0
-3σ -2σ -1σ µ 1σ 2σ 3σ
Dose
ACUTE TOXICITY - ANIMAL STUDIES
50
40
Response
30
A B
20
10
Dose
Comparison of Dose-Response Curves
50
D
40
Response
30
20
10 C
Dose
SELECTIVE TOXICITY
Toxicological testing with animals is
complicated by the fact that different species
respond differently to the same chemicals.
This may be due to:
Oxidation hydrolysis
(microsomal enzymes) and binding
MALAOXON PRODUCTS
(active) (inactive)
hydrolysis
(A - esterases)
slow - insect
rapid - mammal
TOXIC EFFECTS
Local vs Systemic toxicology
Local - Irritant chemicals when inhaled produce
local toxic effects in the lungs. e.g. HCl, NH3